Bioactive Products
| A unique collection of 223 Neuroprotection natural compounds for high throughput screening (HTS) | ||
| Catalog No: | B72a21 | Neuroprotection Compound Library Screening Details |
| Size: | 1mg/well * 223 Compounds 2mg/well * 223 Compounds | |
| Cat. No. | Information |
| CFN98157 | Tenuifolin Tenuifolin is one of the active constituents of HPS against the neurotoxicity induced by Aβ25-35 peptides in vitro and in vivo, it possesses neuroprotective effects against Aβ25-35-induced apoptosis in PC12 cells and significantly improves the cognitive deficits induced by the intrahippocampal injection of Aβ25-35 in mice. |
| CFN98344 | Reynosin Reynosin has hepatoprotective, and anti-inflammatory effects, it has protective effect against dopamine-induced neuronal cell death, which may be due to the reciprocal up-regulation of E6-associated protein and down-regulation of α-synuclein protein expression. Reynosin exhibits a dose-dependent inhibition on CINC-1 induction in LPS-stimulated NRK-52E cells, where 50% of inhibitory effect was shown at the concentration of about 1 microM. Reynosin also has strong anti-mycobactericidal activity, with a minimal bactericidal concentration (MBC) of 128ug/mL against the H37Rv, 366-2009 and 104-2010 Mtb strains and a minimal inhibitory concentration (MIC) of 64, 64, 128, 128 and 128ug/mL against the H37Rv, 104-2010, 63-2009, 366-2009 and 430-2010 Mtb strains, respectively. |
| CFN98368 | Oxyresveratrol Oxyresveratrol , a dietary phenolic compound, has neuroprotective effect, as a potential nutritional candidate for protection against neurodegeneration in Parkinson disease; Oxyresveratrol has antioxidant activity, can reduce neuronal oxidative damage and protect hepatocytes against oxidative stress and mitochondrial dysfunction, which may be associated with activation of Nrf2, it also as an antibrowning agent for cloudy apple juices and fresh-cut apples. Oxyresveratrol exhibits a potent inhibitory effect on dopa oxidase activity of tyrosinase which catalyzes rate-limiting steps of melanin biosynthesis.Oxyresveratrol exhibits the inhibitory activity at the early and late phase of viral replication and inhibited the viral replication with pretreatment in one-step growth assay of HSV-1 and HSV-2. |
| CFN98400 | Isobavachin Isobavachin can stimulate osteoblasts proliferation and differentiation; it also can facilitate mouse embryonic stem cells differentiating into neuronal cells, the mechanism involved protein prenylation and, subsequently, phos-ERK activation and the phos-p38 off pathway. Isobavachin possesses estrogen-like activity in MCF-7/BOS cells, it can significantly stimulate the proliferation of MCF-7/BOS cells in a dose-dependent manner. Isobavachin has cytotoxic effects on H4IIE hepatoma and metabolically poorly active C6 glioma cells. |
| CFN98404 | Pinusolide Pinusolide is a platelet activating factor ( PAF) antagonist, it may prove of therapeutic value in the treatment of hypotension, it has antileukemic potential, and could be used to treat neurodegenerative diseases. Pinusolide attenuates blockade of insulin signaling by enhancing IRS-1 tyrosine phosphorylation by the activating the AMPK pathway, indicates the targeting of AMPK represents a new therapeutic strategy for hyperglycemia-induced insulin resistance and type 2 diabetes. |
