1. Bis(2-ethylhexyl) phthalate (DEHP) is a compound widely used in plastics technology to impart flexibility to rigid polymers, DEHP has oral toxicity during pregnancy and suckling in the Long-Evans rat.
2. Bis(2-ethylhexyl) phthalate and Perinatal butyl benzyl phthalate (BBP) can induce antiandrogenic effects in Spague-Dawley (SD) rats.
3. Bis(2-ethylhexyl) phthalate has toxic or endocrine disrupting effects on aquatic species in water bodies.
4. Bis-(2-ethylhexyl) phthalate is the most commonly used plasticizing agent for the widely used plastic polyvinylchloride (PVC), is an ubiquitous environmental contaminant, many workers have demonstrated its exceedingly low acute toxicity, while results from chronic exposure studies have been mixed.
5. In 1982 the National Toxicology Program reported a significantly increased incidence of hepatocellular carcinoma in rats and mice exposed to high doses of DEHP over a period of two years.