Bioactive Products
| A unique collection of 50 Pro-apoptotic natural compound library for Pro-apoptotic screening | ||
| Catalog No: | B93 | Pro-apoptotic Compound Library Screening Details |
| Size: | 1mg/well * 50 Compounds 2mg/well * 50 Compounds | |
| Cat. No. | Information |
| CFN90741 | Flavokawain C Flavokawain C is a melanogenesis inhibitor, it inhibited melanogenesis with IC50 values of 6.9 uM. Flavokawain C has anti-tumor activity, it inhibited cell cycle and promoted apoptosis, associated with endoplasmic reticulum stress and regulation of MAPKs and Akt signaling pathways in HCT 116 human colon carcinoma cells. |
| CFN90757 | Ginsenoside F4 Ginsenoside F4 has inhibitory effect on human lymphocytoma JK cell by inducing its apoptosis, the mechanism is related to the mitochondrial dysfunction and the increase of Bax expression and decrease of Bcl-2 expression. Ginsenoside F4 also has strongly inhibit activation of p38 mitogen-activated protein kinase in signal transduction pathways. |
| CFN90771 | Bruceine D Bruceine D has anti-cancer activity, it inhibits the growth of three pancreatic cancer cell lines, i.e., PANC-1, SW1990 and CAPAN-1; induces cytotoxicity in Capan-2 cells via the induction of cellular apoptosis involving the mitochondrial pathway.Bruceine D may have the potential to be used as a natural viricide, or a lead compound for new viricides. |
| CFN93993 | Gliotoxin Gliotoxin, a Wnt signaling pathway inhibitor, induces growth inhibition and apoptosis in multiple colorectal cancer cell lines with mutations of the Wnt signaling pathway. Gliotoxin targets nuclear NOTCH2 in human solid tumor derived cell lines in vitro and inhibits melanoma growth in xenograft mouse model. Gliotoxin exhibits very strong anti-tuberculosis activity towards Mycobacterium tuberculosis with the the prominent MIC50 value of <0.03 uM. Gliotoxin also suppresses macrophage immune function by subverting phosphatidylinositol 3,4,5-trisphosphate homeostasis. |
| CFN90889 | Sodium Dichloroacetate Sodium dichloroacetate is a drug with potential for treating patients with stroke and head injury. Sodium dichloroacetate exhibits anti-leukemic activity in B-chronic lymphocytic leukemia (B-CLL) and synergizes with the p53 activator Nutlin-3; it is cytoprotective to some colorectal cancer cells under hypoxic conditions. |
