1. Sennoside A may decrease AQP3 expression in the colon to inhibit water transport from the luminal to the vascular side, leading to a laxative effect; Anthraquinones can increase its purgative action.
2. Sennoside A is a new dual HIV-1 inhibitor effective on HIV-1 replication.
3. Sennoside A and Sennoside B have protective effects on gastric lesion.
1. Sennoside A and sennoside B possess significant gastroprotective activities and they might be useful for the treatment of gastric disease.
2. Sennoside B has a potential utility in the treatment of proliferative diseases, through inhibiting PDGF-stimulated cell proliferation by binding to PDGF-BB and its receptor and by down-regulating the PDGFR-beta signaling pathway.
3. Sennoside B, a major purgative component.
1. Sennoside C , aloe-emodin anthrone and rhein anthrone which formed mainly by intraluminal bacterial action, synergistically exert their purgative effects on mice.
1. Plants containing aloin A, aloe emodin, and structurally related anthraquinones have long been used as traditional medicines and in the formulation of retail products such as laxatives, dietary supplements, and cosmetics; however, topically applied aloe emodin increases the sensitivity of skin to UV light, although aloin A is not directly photocytotoxic, but human skin fibroblasts can metabolize aloin A to aloe emodin.
2. Aloin A and aloe emodin have antibacterial activity against Gram-positive and Gram-negative bacteria.