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  • Bioactive Products
    Catalog No. Information
    CFN99397 Scoparinol

    1. Scoparinol has sedative action.
    2. Scoparinol has anti-inflammatory activity.
    3. Scoparinol has significant analgesic activity.
    4. Scoparinol has significant diuretic action.
    CFN99547 Betaine hydrochloride

    1. Betaine hydrochloride has protective effects against hypoxic mice.
    2. Betaine hydrochloride can increase the secreting of thyroxine (T3) and insulin and regulate the metabolism of organism by the hormones, thus it prompts fish growth and also improves intestine figuration.
    3. Betaine hydrochloride shows promise for treatment of nonalcoholic steatohepatitis.
    4. Betaine hydrochloride has sedative, antipyretic and analgesic effects.
    CFN99553 Tetrahydropalmatine

    1. l-Tetrahydropalmatine can ameliorate behavioral phenotype induced by METH through regulation of 5-HT neuronal activity and dopamine D3 receptor expression.
    2. Tetrahydropalmatine has a promyogenic effect by upregulation of p38MAPK and Akt resulting in enhanced MyoD activation, suggests that it has a potential as a therapeutic candidate to prevent fibrosis and improve muscle regeneration and repair.
    3. DL-tetrahydropalmatine acts through the 5-HT2 and/or D2-receptor antagonism in the hypothalamus to induce hypotension and bradycardia in rats.
    4. DL-tetrahydropalmatine (dl-THP) has been intensively studied for its sedative and hypnotic effects,dl-THP at defined low dosages acts as anxiolytics in mice, and the benzodiazepine site (BDS) mediates, at least in part, such anxiolytic effect of dl-THP.
    5. Tetrahydropalmatine can effectively protect endothelial cells against γ-irradiation injury, which can potentially be applied to the prevention of endothelial cell dysfunctions associated with ionizing irradiation-induced lung injury.
    6. Levo-tetrahydropalmatine inhibits cocaine's rewarding effects.
    CFN99581 Neferine

    1. Neferine shows significant improvement in cognitive impairment in scopolamine-induced amnesia animal models and moderate inhibitory activities, the anti-amnesic effect of neferine may be mediated via antioxidant and anti-inflammatory capacities, as well as inhibition of ChEs and BACE1.
    2. Neferine induces autophagy through the inhibition of PI3K/Akt/mTOR pathway and ROS hyper generation in A549 cells.
    3. Neferine attenuates bleomycin-induced pulmonary fibrosis in vitro and in vivo, the beneficial effect of neferine may be associated with its activities of anti-inflammation, antioxidation, cytokine and NF-kappaB inhibition.
    4. Neferine has effects similar to rosiglitazone in decreasing fasting blood glucose, insulin, triglycerides (TG), tumor necrosis factor-alpha (TNF-alpha) and enhancing insulin sensitivity in insulin resistant rats.
    5. Neferine inhibits proliferation of human osteosarcoma cells by promoting p38 MAPK-mediated p21 stabilization.
    6. Neferine shows anti-anxiety effects and that neferine may participate in the efficacy of the sedative effects of embryos of the seeds of Nelumbo nucifera, the mechanisms of the sedative effects of neferine are not similar to those of diazepam.
    7. Neferine possesses a significant inhibitory effect on amiodarone-induced pulmonary fibrosis, probably due to its properties of anti-inflammation, surfactant protein-D (SP-D) inhibition and restoring increased CD4+CD25+ Tregs which may modulate Th1/Th2 imbalance by suppressing Th2 response.
    8. Neferine shows antidepressant-like effects in mice similar to typical antidepressants and that these effects are mediated by the 5-HT 1A receptor.
    9. Neferine exerts strong antioxidant property against isoproterenol-induced oxidative stress and can be used as a potent cardioprotective agent against isoproterenol-induced myocardial infarction.
    CFN99582 Linalool

    1. Linalool possesses anti-inflammatory, antinociceptive, and other bioactive properties; it can attenuate the production of LPS-induced tumor necrosis-α and interleukin-6 bothand, block the phosphorylation of IκBαprotein, p38, c-Jun terminal kinase, and extracellular signal-regulated kinase in LPS-stimulated RAW 264.7 cells.
    2. Linalool-rich essential oil is a strikingly potent leishmanicidal plant extract (50% lethal doses, 8.3 ng/ml for promastigotes and 8.7 ng/ml for amastigotes) which inhibited the growth of L. amazonensis promastigotes at very low concentrations (MIC, 85.0 pg/ml).
    3. The purified linalool fraction is only inhibitory for C. albicans.
    4. Linalool has dose-dependent marked sedative effects at the central nervous system (CNS), including hypnotic, anticonvulsant and hypothermic properties, it has been suggested that these neurochemical effects might be ascribed to the local anaesthetic activity of linalool, linalool also has an inhibitory effect on the acetylcholine (ACh) release and on the channel open time in the mouse neuromuscular junction.
    5. Linalool, myrcene and eucalyptol have protective effect against t -butyl hydroperoxide induced genotoxicity in bacteria and cultured human cells, they also have insecticidal activity.
    6. Inhaling linalool rich essential oils can be useful as a mean to attain relaxation and counteract anxiety.