1. Nonivamide and capsaicin are novel skin permeation enhancers for indometacin.
2. Nonivamide has antioxidant activity, it has the efficacy to protect linoleic and cholesterol against free radical attack.
3. Nonivamide may be effective anti-obesity agents by reducing energy intake, enhancing energy metabolism, decreasing serum triacylglycerol content, and inhibiting adipogenesis via activation of the transient receptor potential cation channel subfamily V member 1 (TRPV1).
4. Nonivamide exploits an anti-inflammatory effect by inhibiting the EC-LPS induced activation of the MAPK pathway in U-937 macrophages, in addition, the TRP channel activation plays a role in the anti-inflammatory capacity of capsaicin and nonivamide.