1. Liquiritin has a potential antidepressant-like effect.
2. Liquiritin can increase SOD activity, inhibit lipid peroxidation, and lessen production of MDA.
3. Liquiritin modulates ERK‑ and AKT/GSK‑3β‑dependent pathways to protect against glutamate‑induced cell damage in differentiated PC12 cells.
|CFN99161||Salvianolic acid A
1. Salvianolic acid A has anti-oxidative capability.
2. Salvianolic acid A positively regulates PTEN protein level and inhibits growth of A549 lung cancer cells.
3. Salvianolic acid A inhibits proliferation, causes cell cycle arrest at the S phase, and induces apoptosis dose dependently to the two kinds of cancer cells.
4. Salvianolic acid A has inhibitory effect on Cu2+ mediated human LDL oxidation through chelating Cu2+ and scavenging free radicals.
5. Salvianolic acid A could protect hepatic lipid peroxidation, and had marked effects against liver injur y and fibrosis in carbon tetrachloride induced fibrotic rats.
6. Salvianolic acid A has inhibitory effect on Cu2+ mediated human LDL oxidation through chelating Cu2+ and scavenging free radicals.
7. Salvianolic acid A can reverse paclitaxel resistance through suppressing transgelin 2 expression by mechanisms involving attenuation of PI3 K/Akt pathway activation and ABC transporter up-regulation.
1. Ginkgolide A has neuroprotective effects.
2. Ginkgolide A is widely used for the treatment of cardiovascular diseases and diabetic vascular complications, which might be achieved through regulating the STAT3-mediated pathway.
3. Ginkgolide A could increase cell viability and suppress the phosphorylation level of Tau in cell lysates, meanwhile, GSK3β was inhibited with phosphorylation at Ser9.
4. Ginkgolide A promoted phosphorylation of PI3K and Akt, suggesting that the activation of the PI3K-Akt signaling pathway may be the mechanism to prevent the intracellular accumulation of p-Tau induced by okadaic acid and to protect the cells from Tau hyperphosphorylation-related toxicity.
1. Cyanidin-3-O-glucoside,as well as other phytochemicals recognized as potent antioxidants and free radical scavengers, may act as modulators of gene regulation and signal transduction pathways.
(1) It is able to protect human endothelial cells against alterations induced by TNF-α, including the activation of NF-κB;
(2) Increased gene expression of adhesion molecules, leukocyte adhesion to endothelium, intracellular accumulation of H2O2 and lipid peroxidation byproducts.
1. Bilirubin is a potent antioxidant.
2. Bilirubin may compromise cellular metabolism and proliferation via induction of ER stress.