Oxypeucedanin

Oxypeucedanin is a major coumarin aglycone that can be extracted from Ostericum koreanum, coumarin aglycones have demonstrated various pharmacological effects, including anti-proliferation, anti-inflammation, and anti-pain; based on transcriptional alteration and complicated modulation of MAPK signaling, might be underlying mechanisms responsible for the various pharmacological effects of oxypeucedanin.^[1]

Oxypeucedanina has a novel anticancer effect, mediated via induction of G2-M cell cycle arrest and apoptosis in human prostate carcinoma DU145 cells.^[2]

Oxypeucedanin is a kind of open-channel blocker of the hKv1.5 channel and it prolongs the APD, therefore, it is an excellent candidate as an antiarrhythmic drug for atrial fibrillation.^[3]

Oxypeucedanin and osthole have protective effects on doxorubicin -induced apoptosis in PC12 cells.^[4]

Oxypeucedanin has hypotensive effects , the effect is related to dilate blood vessels.^[5]

Oxypeucedanin has antidiarrheal and anti-inflammatory effects .^[6]

[1] Choi J S, Shin H Y, Kwon K S, et al. Planta Med, 2011, 77(13):1512-8.

[2] Kang T J, Lee S Y, Singh R P, et al. Acta Oncologica, 2009, 48(6):895-900.

[3] Eun J S, Park J A, Choi B H, et al. Biol Pharm Bull, 2005, 28(4):657-60.

[4] Moieniarya M, Shookohinia Y, Hosseinzadeh L, et al. Res Pharm Sci, 2012, 7(5).

[5] Tang C. Chinese Journal of Modern Applied Pharmacy, 1994(01):14-16.

[6] Zhang M, Shen Y. Chinese Traditional & Herbal Drugs, 1996(12):727-9.

[7] Paramapojn S, Gritsanapan W, Ganzera M, et al. Planta Med, 2008, 74(9):1089.