Eurycomanone

Eurycomanone has cytotoxic on HepG2 cells and Human Cervical Carcinoma Cells by inducing apoptosis through the up-regulation of p53 and Bax, and down-regulation of Bcl-2.^[1,2]

Eurycomanone exerts antiproliferative activity via apoptosis in Hela cells MCF-7cells .^[3,4] and

Eurycomanone at viable therapeutic concentrations of 5–20μg/ml exhibits significant anti-proliferative and anti-clonogenic cell growth effects on A549 lung cancer cells, the treatment also resulted in suppression of the lung cancer cell tumor markers and several known cancer cell growth-associated genes.^[5]

Eurycomanone enhances testosterone steroidogenesis at the Leydig cells by inhibiting aromatase conversion of testosterone to oestrogen, and at a high concentration may also involve phosphodiesterase inhibition, it may be worthy for further development as a phytomedicine to treat testosterone-deficient idiopathic male infertility and sterility.^[6]

Eurycomanone and eurycomanol as regulators of signaling pathways involved in proliferation, cell death and inflammation.^[7]

Eurycomanone possesses growth inhibition of P. berghei by combination of eurycomanone-artesunate with doses 30 mg/kgBW-artesunate 4mg/kgBW, suggests that this combination can be used as potential antimalarial drug.^[8]

[1] Zakaria Y, Rahmat A, Pihie A H L, et al. Cancer Cell Int, 2009, 9(1):1-21.

[2] Mahfudh N, Pihie A H L. J Cancer Mol, 2008, 4(4):109-15.

[3] Nurkhasanah, Azimahtol Hawariah Lope Pihie,Jalifah Latip. Majalah Farmasi Indonesia, 2009, 20(4): 190-7.

[4] Pihie A H L. Anticancer Res, 2004, 24(5D):3426-7.

[5] Wong P F, Cheong W F, Shu M H, et al.Phytomedicine, 2012, 19(2):138-44.

[6] Low B S, Choi S B, Wahab H A, et al. J Ethnopharmacol, 2013, 149(1):201-7.

[7] Hajjouli S, Chateauvieux S, Teiten M H, et al. Molecules, 2014, 19(9):14649-66.

[8] Yusuf H, Satria D. J Chem Pharm Res, 2016,(82):18-22.

[9] Khari N, Aisha A, Ismail Z. Trop J Pharm Res, 2014, 13(5):801-7.