Vicenin -2

Vicenin-2 (VCN-2), an active constituent of the medicinal herb Ocimum Sanctum Linn or Tulsi, it can effectively induce anti-proliferative, anti-angiogenic and pro-apoptotic effect in CaP cells (PC-3, DU-145 and LNCaP) irrespective of their androgen responsiveness or p53 status;VCN-2 in combination with docetaxel (DTL) synergistically inhibited the growth of prostate tumors in vivo with a greater decrease in the levels of AR, pIGF1R, pAkt, PCNA, cyclin D1, Ki67, CD31, and increase in E-cadherin; it could as a single agent and in combination with DTL in carcinoma of prostate (CaP). ^[1]

Vicenin-2 has potential anti-inflammatory activity, can modify LPS-induced total nitrite and TNF-α production, in addition to the LPS-induced translocation of the nuclear factor NF-κB.^[2]

vicenin-2 and scolymoside, can suppress high-glucose (HG)-induced vascular inflammatory processes in human umbilical vein endothelial cells (HUVECs) and mice, HG-induced vascular inflammatory responses are critical events underlying the development of various diabetic complications; therefore, suggests that vicenin-2 and scolymoside have significant therapeutic benefits against diabetic complications and atherosclerosis.^[3]

Vicenin-2 or scolymoside can reduce cecal ligation and puncture (CLP)-induced septic mortality and pulmonary injury, indicate that vicenin-2 and scolymoside could be a potential therapeutic agent for treatment of various severe vascular inflammatory diseases via inhibition of the TGFBIp signaling pathway.^[4]

Vicenin-2 has antithrombotic and antiplatelet activities.^[5]

[1] Nagaprashantha L D, Vatsyayan R, Singhal J, et al. Biochem Pharmacol, 2011, 82(9):1100-9.

[2] Marrassini C, Davicino R, Acevedo C, et al. J Nat Prod, 2011, 74(6):1503-7.

[3] Ku S K, Bae J S. Can J Physiol Pharm, 2016, 3(1): 287-95.

[4] Lee W, Ku S K, Bae J S. Inflammation, 2015, 38(6):2166-77.

[5] Lee W, Bae J S. Blood Coagul Fibrin, 2015, 26(6):628-34. 

[6] Qin L U. China Pharmacy, 2015(30):4271-3.