Natural Products
Shanzhiside methylester
| Catalog No. | CFN97107 |  |
| CAS No. | 64421-28-9 | |
| Molecular Weight: | 406.4 | |
| Molecular Formula | C17H26O11 | |
| DBs | [PubChem]:274953275 [ChEMBL]: [PCIDB]:10687 |
Standard InChI:
InChI=1S/C17H26O11/c1-17(24)3-7(19)9-6(14(23)25-2)5-26-15(10(9)17)28-16-13(22)12(21)11(20)8(4-18)27-16/h5,7-13,15-16,18-22,24H,3-4H2,1-2H3/t7-,8?,9+,10-,11-,12?,13+,15+,16-,17+/m1/s1
Biological Activity
Shanzhiside methylester, the principle effective iridoid glycoside from the analgesic herb Lamiophlomis rotata , reduces neuropathic pain by activating spinal GLP-1 receptors and subsequently stimulating microglial β-endorphin expression via the p38 MAPK signaling; stimulation of the endogenous β-endorphin expression may be a novel and effective strategy for the discovery and development of analgesics for the long-term treatment of chronic pain. [1]
Product
Official website: Shanzhiside methylester
Japanese website: Shanzhiside methylester
Chinese website: Shanzhiside methylester
Japanese website: Shanzhiside methylester
Chinese website: Shanzhiside methylester
References
[1] Fan H, Li T F, Gong N, et al. Neuropharmacol, 2015, 101:98-109.
[2] Xi H E, Mao X, Fan P C, et al. Chinese J Exp Trad Med Formulae. 2010, 16(07):50-2
Product Use Citation
