Jujuboside B

Catalog No.	CFN98102
CAS No.	55466-05-2
Molecular Weight:	1045.22
Molecular Formula	C52H84O21
DBs	[PubChem]:274952405 [ChEMBL]: [PCIDB]:

Standard InChI:

InChI=1S/C52H84O21/c1-22(2)15-24-16-50(8,63)42-25-9-10-30-48(6)13-12-31(47(4,5)29(48)11-14-49(30,7)51(25)20-52(42,73-24)66-21-51)69-45-41(72-44-38(62)35(59)32(56)23(3)67-44)39(27(55)19-65-45)70-46-40(36(60)34(58)28(17-53)68-46)71-43-37(61)33(57)26(54)18-64-43/h15,23-46,53-63H,9-14,16-21H2,1-8H3/t23-,24+,25+,26+,27-,28+,29-,30+,31-,32-,33-,34+,35+,36-,37+,38+,39-,40+,41+,42-,43-,44-,45-,46-,48-,49+,50-,51-,52-/m0/s1

Biological Activity

Jujuboside B is one of the saponins isolated from the seeds of Zizyphus jujuba var, has

antitumor activity and the underlying mechanism via induction of apoptosis and autophagy.^[1]

Jujuboside B has potent inhibitory effects on collagen-, thrombin-, AA-, and ADP-induced aggregation, also exhibits superior protection on thromboembolic model, it has a significant inhibitory effect on collagen-induced thromboxane A2 production in rat platelets; suggest that it be considered as components of preventive and therapeutic herbal drugs targeting cardiovascular diseases associated with platelet hyperaggregation.^[2]

Jujuboside B reduces vascular tension endothelium-dependently by increasing Ca2+Influx and activating endothelial nitric oxide synthase, it is a natural compound with new pharmacological effects on improving endothelial dysfunction and treating vascular diseases.^[3]