Natural Products
Praeruptorin C
| Catalog No. | CFN98143 |  |
| CAS No. | 72463-77-5 | |
| Molecular Weight: | 428.48 | |
| Molecular Formula | C24H28O7 | |
| DBs | [PubChem]:274952364 [ChEMBL]: [PCIDB]: |
Standard InChI:
InChI=1S/C24H28O7/c1-7-14(4)23(27)30-22-21(29-18(26)12-13(2)3)19-16(31-24(22,5)6)10-8-15-9-11-17(25)28-20(15)19/h7-11,13,21-22H,12H2,1-6H3/b14-7+/t21-,22-/m1/s1
Biological Activity
Praeruptorin C (Pra-C), one of the principal bioactive components derived from the root of Peucedanum praeruptorum Dunn, has been widely used as an antioxidant and a calcium antagonist to treat diseases, Pra-C partially also protects cortical neurons by inhibiting the expression of GluN2B-containing NMDA receptors and regulating the Bcl-2 family.[1]
Praeruptorin C can completely inhibit SMC proliferation induced by Ang II and partly inhibit the growth of SMC- induced by bovine serum, which is important in prevention and treatment of vascular hyperplastic disease.[2]
Praeruptorin C can attenuate the level of NCX mRNA , has cardioprotective effect on NCX mediates during ischemia/reperfusion in the neonatal rat cardiomyocytes I/R model; cardioprotection induced by hypoxia preconditioning and praeruptorin C preconditioning against hypoxia-reoxygenation injury may be related with upregulating phospholamban phosphorylation.[3,4]
Product
References
[1] Yang L, Li X B, Yang Q, et al. Toxicol in Vitro, 2013, 27(2):908-14.
[2] Wei E H, Rao M R, Chen X Y, et al.Acta Pharmacol Sin, 2002, 23(2):129-32.
[3] Qun-Ying X I, Zhu B H, Liu C, et al. Chinese Heart Journal, 2008(5):513-6.
[4] Chen K X, Zhu B H, Liu C. Chinese Journal of Geriatric Heart Brain & Vessel Diseases, 2008, 10(3):210-3.
[5] Xu G B, Liu S J, Liang Y M, et al.Traditional Chinese Medicine, 2007, 32 (19): 2069-71.
Product Use Citation
