Natural Products
Geniposidic acid
| Catalog No. | CFN98337 |  |
| CAS No. | 27741-01-1 | |
| Molecular Weight: | 374.3 | |
| Molecular Formula | C16H22O10 | |
| DBs | [PubChem]:274952083 [ChEMBL]:5301 [PCIDB]: |
Standard InChI:
InChI=1S/C16H22O10/c17-3-6-1-2-7-8(14(22)23)5-24-15(10(6)7)26-16-13(21)12(20)11(19)9(4-18)25-16/h1,5,7,9-13,15-21H,2-4H2,(H,22,23)/t7-,9-,10-,11-,12+,13-,15+,16+/m1/s1
Biological Activity
Geniposidic acid, one of the main active ingredients in Gardenia jasminoides J. Ellis (Rubiaceae), has anti-atherosclerotic effects, can protect vascular endothelium and reverse plaque formation in an atherosclerotic model.[1]
Geniposidic acid and geniposide have antitumor effects , play a role in an effective anticancer product with the ability to decrease undesirable radiation damage to the hematologic tissue after high dose irradiation.[2]
Geniposidic acid can protect against D-galactosamine and lipopolysaccharide-induced hepatic failure in mice.[3]
Geniposidic acid protects against anti-induced hepatotoxity and acute intrahepatic cholestasis, due to Fxr-mediated regulation of Bsep and Mrp2.[4]
Geniposidic acid has effects on the expression of MRP2 and BSEP in BRL-3A cells after FXR gene silencing mediated by si RNA.[5]
Product
Official website: Geniposidic acid
Japanese website: Geniposidic acid
Chinese website: Geniposidic acid
Japanese website: Geniposidic acid
Chinese website: Geniposidic acid
References
[1] Yu G, Zi-Yu C, Xue L, et al. Pharm Biol, 2014, 53(2):1-6.
[2] Hsu H Y, Yang J J, Lin S Y, et al. Cancer Lett, 1997, 113(1-2):31-7.
[3] Kim S J, Kim K M, Park J, et al. J Ethnopharmacol, 2013, 146(1):271-7.
[4] Chen H, Huang X, Min J, et al. J Ethnopharmacol 2015, 179:197-207.
[5] Chen H, Shi S, Min J B, et al.China Journal of Traditional Chinese Medicine & Pharmacy, 2016,5.
[6] Peng M J, Zhang M, Liu J L, et al. Chinese Journal of Hospital Pharmacy, 2005, 25(04):300-2.
Product Use Citation
