Natural Products
Aromadendrin
| Catalog No. | CFN98736 |  |
| CAS No. | 480-20-6 | |
| Molecular Weight: | 288.3 | |
| Molecular Formula | C15H12O6 | |
| DBs | [PubChem]:274951768 [ChEMBL]: [PCIDB]: |
Standard InChI:
InChI=1S/C15H12O6/c16-8-3-1-7(2-4-8)15-14(20)13(19)12-10(18)5-9(17)6-11(12)21-15/h1-6,14-18,20H/t14-,15+/m0/s1
Biological Activity
Aromadendrin, a flavonol, has been reported to possess a variety of pharmacological activities such as anti-inflammatory, antioxidant, and anti-diabetic properties, it exhibits anti-inflammatory activity through the suppression of nuclear translocation of NF-κB and phosphorylation of JNK in LPS-stimulated RAW 264.7 macrophage cells.[1]
Aromadendrin treatment induces adipogenesis by increases in PPARγ2 expression, resulting in stimulation of glucose uptake and ameliorated insulin resistance, suggests that it may represent a potential therapeutic candidate for the management of type 2 DM.[2]
Aromadendrin, from prickly pear ( Opuntia ficus-indica ) root, has inhibitory activity on aldose reductase and the formation of advanced glycation end products.[3]
Product
References
[1] Lee J W, Kim N H, Kim J Y, et al. Biomol Ther, 2013, 21(3):216-21.
[2] Zhang W Y, Lee J J, Kim I S, et al. Pharmacology, 2011, 88(5-6):266-74.
[3] Jeon Y E, Yin X F, Dan B C, et al. Food Sci Biotechnol, 2011, 20(5):1283-8.
[4] Chen Y, Gong M, Zhang C, et al. China journal of Chinese Materia Medica, 2010, 35(19):2565-7.
Product Use Citation
