Sphondin

Sphondin, a furanocoumarin derivative isolated from Heracleum laciniatum, possesses an inhibitory effect on IL-1beta-induced increase in the level of COX-2 protein and PGE(2) release in A549 cells, the inhibitory mechanism, at least in part, through suppression of NF-kappaB activity, suggests that sphondin may have the therapeutic potential as an anti-inflammatory drug on airway inflammation.^[1]

Sphondin, 8-methoxypsoralen, and khellin have delayed phototoxic effects inAedes aegypti.^[2]

Sphondin has NO production inhibitory activity, due to the effect of iNOS expression, but not by direct inhibition of iNOS enzyme activity, thus, sphondin may act as a potent inhibitor of NO production under tissue-damaging inflammatory conditions.^[3]

Sphondin, one of furanocoumarins isolated from the fruits of the plant, may have anticonvulsant activity.^[4]

Sphondin shows anti-proliferative activity and causes G2/M arrest at concentrations of 0.05-15.0 uM, it may have anti-tumor effects.^[5]

[1] Yang L L, Liang Y C, Chang C W, et al. Life Sci, 2002, 72(2):199-213.

[2] Kagan J, Szczepanski P, Bindokas V, et al. J Chem Ecol, 1986, 12(4):899-914.

[3] Wang C C, Lai J E, Chen L G, et al. Bioorg Med Chem, 2000, 8(12):2701-7.

[4] Tosun F, Çiğdem Akyüz Kızılay, Erol K, et al. Food Chem, 2008, 107(3):990-3.

[5] Sumiyoshi M, Sakanaka M, Taniguchi M, et al. J Nat Med, 2013, 68(1):83-94.

[6] Fatma M. Al-Barwani, Elsadig A. Eltayeb. SQU Journal For Science, 2004,(9): 7-17.