Natural Products
Euscaphic acid
| Catalog No. | CFN98888 |  |
| CAS No. | 53155-25-2 | |
| Molecular Weight: | 488.7 | |
| Molecular Formula | C30H48O5 | |
| DBs | [PubChem]:274951617 [ChEMBL]:67914 [PCIDB]:19491 |
Standard InChI:
InChI=1S/C30H48O5/c1-17-10-13-30(24(33)34)15-14-27(5)18(22(30)29(17,7)35)8-9-21-26(4)16-19(31)23(32)25(2,3)20(26)11-12-28(21,27)6/h8,17,19-23,31-32,35H,9-16H2,1-7H3,(H,33,34)/t17-,19-,20+,21-,22-,23-,26+,27-,28-,29-,30+/m1/s1
Biological Activity
Euscaphic acid, isolated from roots of Rosa rugosa, inhibits LPS-induced inflammatory responses by interference with the clustering of TRAF6 with IRAK1 and TAK1, resulting in blocking the activation of IKK and MAPKs signal transduction to downregulate NF-κB activations.[1]
Euscaphic acid and tormentic acid from the roots of Rosa rugosa have inhibitory effect on high fat diet-induced obesity in the rat.[2]
Euscaphic acid has anti-contraction effects on rat's aortic smooth muscle.[3]
Product
References
[1] In-Tae Kim †, Suran Ryu †, Ji-Sun Shin †, et al. J Cell Biochem, 2012, 113(6):1936–46.
[2] Park H J, Nam J H, Jung H J, et al. Korean J Pharmacogn, 2005, 36(4):324-31.
[3] Mahmud S A. Adv Life Sci Technol, 2015, 33.
[4] Pan P, Jia L, Sun Q. Chinese J Pharm Anal, 2007, 27:841-3.
Product Use Citation
