Tanshinone I

Tanshinone I, a major active principle of Salvia miltiorrhiza (Danshen), has been shown to overcome tumor drug resistance and metastasis, it inhibits angiogenesis, inhibits proliferation, migration and tube formation of vascular endothelial cells, rat aortic ring sprouting and the neovascularization of the chick chorioallantoic membrane in a concentration-dependent manner; it as promising angiogenesis inhibitors.^[1]

Tanshinone I can suppress growth and invasion of human breast cancer cells, MDA-MB-231, through regulation of adhesion molecules.^[2]

Tanshinone I, tanshinone IIA and cryptotanshinone, can protect against liver toxicity in vivo and in vitro due to its antioxidant effects.^[3]

Tanshinone I exerts neuroprotection in cerebrovascular diseases including transient ischemic attack, it can promote neurogenesis in the mouse DG and that the neurogenesis is related with increases of Wnt-3, p-GSK-3β and β-catenin immunoreactivities.^[4]

Tanshinone I can effectively induce apoptosis in estrogen receptor-positive (MCF-7) and estrogen receptor-negative (MDA-MB-231) breast cancer cells; it has growth inhibition and apoptosis induction in human colon cancer Colo 205 cells.^[5]

Tanshinone I enhances learning and memory, and ameliorates memory impairment in mice via the extracellular signal-regulated kinase signalling pathway.^[6,7]

[1] Wang Y, Li J X, Wang Y Q, et al. Oncotarget, 2015, 6(18):16031-42.

[2] Nizamutdinova I T, Lee G W, Lee J S, et al. Carcinogenesis, 2008, 29(10):1885-92.

[3] Park E J, Zhao Y Z, Kim Y C, et al. Food Chem Toxicol , 2009, 47(11):2742-8.

[4] Bai H C, Park J H, Cho J H, et al. Neurochem Res, 2016,41(8):1958-68.

[5] Nizamutdinova IT, Lee GW, Son KH, et al. Int J Oncol, 2008, 33(3):485-91.

[5] Su C C, Chen G W, Lin J G. Int J Mol Med, 2008, 22(5):613-8.

[6] Dong H K, Kim S, Su J J, et al. Brit J Pharmacol, 2009, 158(4):1131-42.

[7] Shi Z, He J, Yao T, et al. J Pharm Biomed Anal, 2005, 37(3):481-6.