Natural Products
Dendrobine
| Catalog No. | CFN99133 |  |
| CAS No. | 2115-91-5 | |
| Molecular Weight: | 263.38 | |
| Molecular Formula | C16H25NO2 | |
| DBs | [PubChem]:274951285 [ChEMBL]:4400 [PCIDB]: |
Standard InChI:
InChI=1S/C16H25NO2/c1-8(2)11-12-10-6-5-9-7-17(4)14(16(9,10)3)13(11)19-15(12)18/h8-14H,5-7H2,1-4H3/t9-,10+,11+,12-,13-,14-,16+/m1/s1
Biological Activity
Dendrobine, isolated from Dendrobium nobile, an antagonist of β-alanine, taurine and of presynaptic inhibition in the frog spinal cord.[1]
Dendrobine has antitumor activity, it can inhibit the growth of A549 cells through inducing apoptosis, which was partially dependent on mitochondrial-mediated pathway; dendrobine treatment decreased mitochondrial membrane potential (MMP), improved the expression of Bax and inhibited the expression of Bcl-2, therefore it was supposed that dendrobine treatment decreased the MMP through regulating the expression of Bcl-2 and Bax; dendrobine releases cytochrome c and promotes caspase 9 activation indicating that dendrobine induces apoptosis is partially caspase-dependent.[2]
Product
References
[1] Yannakopoulou K. Brit J Pharmacol, 1983, 78(4):709–15.
[2] Song T . The HKU Scholars Hub, 2016.
[3] Shen G. Journal of Anhui Agricultural Sciences, 2009, 37(31):15248-9.
Product Use Citation
