Natural Products
Ononin
| Catalog No. | CFN99136 |  |
| CAS No. | 486-62-4 | |
| Molecular Weight: | 430.4 | |
| Molecular Formula | C22H22O9 | |
| DBs | [PubChem]:274951282 [ChEMBL]:7775 [PCIDB]:2553 |
Standard InChI:
InChI=1S/C22H22O9/c1-28-12-4-2-11(3-5-12)15-10-29-16-8-13(6-7-14(16)18(15)24)30-22-21(27)20(26)19(25)17(9-23)31-22/h2-8,10,17,19-23,25-27H,9H2,1H3/t17?,19-,20+,21?,22-/m1/s1
Biological Activity
Ononin, an isoflavonoid, was isolated from the soils of cultivated areas associated with the perennial weed,Pluchea lanceolata, aqueous solutions of this compound can significantly inhibit root and shoot growth of mustard at 1×10(-4) M, 5×10(-4) M, and 1×10(-3)M. [1]
Ononin has weak DPPH·free radical and the superoxide anion free radical scavenging capacity.[2]
Ononin, from Astragalus membranaceus, has an effect on the expression of HIF-1 in a concentration-dependent manner, low concentration could elevate the expression of HIF-1 while high concentration down-regulated the expression; the study provide reference for the anti-tumor effect of A. membranaceus and therapeutic effect of it for other disease.[3]
Product
References
[1] Inderjit, Dakshini K M M. J Chem Ecol, 1992, 18(5):713-8.
[2] Yang H, Han K, Wan X C, et al. J Anhui Agricul Universit, 2011, 38(2):151-5.
[3] Liang L J, Zhao K J, Dong T X, et al. China Pharm, 2010(47):4422-4.
[4] Zhou Q, Ying L I, Dai Y P, et al. Chinese Trad Patent Med, 2014, 36(8):1674-7.
Product Use Citation
