Natural Products
Glycyrrhetinic acid
| Catalog No. | CFN99152 |  |
| CAS No. | 471-53-4 | |
| Molecular Weight: | 470.64 | |
| Molecular Formula | C30H46O4 | |
| DBs | [PubChem]:274951266 [ChEMBL]:30853 [PCIDB]:3521 |
Standard InChI:
InChI=1S/C30H46O4/c1-25(2)21-8-11-30(7)23(28(21,5)10-9-22(25)32)20(31)16-18-19-17-27(4,24(33)34)13-12-26(19,3)14-15-29(18,30)6/h16,19,21-23,32H,8-15,17H2,1-7H3,(H,33,34)/t19-,21-,22-,23+,26+,27-,28-,29+,30+/m0/s1
Biological Activity
Glycyrrhetinic acid, a hydrolysis product of one of the main constituents of licorice, the triterpene glycoside of glycyrrhizic acid, when added to rat liver mitochondria at micromolar concentrations induces swelling, loss of membrane potential, pyridine nucleotide oxidation, and release of cytochrome c and apoptosis inducing factor; indicates that glycyrrhetinic acid is a potent inducer of mitochondrial permeability transition and can trigger the pro-apoptotic pathway.[1]
Glycyrrhetinic acid and some of its derivatives have anti-inflammatory activities.[2]
Glycyrrhizic acid shows no significant affinity for mineralocorticoid or glucocorticoid kidney receptor sites, has a low but definite affinity for mineralocorticoid receptors and thus appears to have a direct mineralocorticoid action. [3]
Glycyrrhetinic acid inhibits renal 11beta-hydroxysteroid dehydrogenase type 2 (11beta-HSD2) and by that mechanism increases access of cortisol to the mineralocorticoid receptor that causes renal sodium retention and potassium loss, decreases plasma potassium concentrations in patients with anuria, and confers Na(+)-retaining properties on glucocorticoids and amplifies those of aldosterone and deoxycorticosterone. [4,5]
Glycyrrhetinic acid has antileukaemic activity.[6]
Glycyrrhetinic acid (10 microM) induces actin disruption and has tumor cell-selective toxic properties, and that its selectivity is superior to those of all the clinically available antitumor agents tested, suggests that it could be utilized as a promising chemopreventive and therapeutic antitumor agent. [7]
Product
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References
[1] Salvi M, Fiore C D, Toninello A. Biochem Pharmacol, 2003, 66(66):2375-9.
[2] Finney R S H, † G F S. J Pharm Pharmacol, 2011, 10(1):613-20.
[3] Ulmann A, Menard J, Corvol P. Endocrinology, 1975, 97(1):46-51.
[4] Morris D J, Semafuko W E, Latif S A, et al. Hypertension, 1992, 20(3):356-60.
[5] Serra A, Uehlinger D E, Ferrari P, et al. J Am Soc Nephrol, 2002, 13(1):191-6.
[6] Logemann W, Lauria F, Cudkowicz G, et al. Nature, 1960, 187(187):607-8.
[7] Yamaguchi H, Noshita T, Yu T. Eur J Med Chem, 2010, 45(7):2943-8.
[8] Ren P, Sun G, Ren P, et al. Asian J Trad Med, 2008(3):110-6.
Product Use Citation
