Astragaloside I

Catalog No.	CFN99172
CAS No.	84680-75-1
Molecular Weight:	869.1
Molecular Formula	C45H72O16
DBs	[PubChem]:274951246 [ChEMBL]:91024 [PCIDB]:50007

Standard InChI:

InChI=1S/C45H72O16/c1-21(47)56-33-24(50)19-55-38(34(33)57-22(2)48)60-28-11-13-45-20-44(45)15-14-41(7)35(43(9)12-10-29(61-43)40(5,6)54)23(49)17-42(41,8)27(44)16-25(36(45)39(28,3)4)58-37-32(53)31(52)30(51)26(18-46)59-37/h23-38,46,49-54H,10-20H2,1-9H3

Biological Activity

AstragalosideΙ(As-Ι), one of the main active ingredients in Astragalus membranaceus, As-I stimulates osteoblast differentiation through the Wnt/β-catenin signaling pathway, which also activates the BMP pathway and RANK pathway, thus highlighting the As-Ιfor pharmaceutical and medicinal applications such as treating bone disease.^[1]

AstragalosideΙmay protect the cerebral tissue against the free radical damage in ischemia.^[2]

AstragalosideΙcan inhibit the activation of BV-2 cells induced by LPS through suppressing the activation of PI3K/Akt/NF-κB pathway, therefore, reduces the nuclear translocation of phosphorylated NF-κB, leading to the down-regulation of the gene expressions of TNF-α, i NOS and IL-1β and thus lessened the production of iNOS, TNF-α and COX-2 protein.^[3]