Astragaloside II

Catalog No.	CFN99173
CAS No.	84676-89-1
Molecular Weight:	827.02
Molecular Formula	C43H70O15
DBs	[PubChem]:274951245 [ChEMBL]:91026 [PCIDB]:35247

Standard InChI:

InChI=1S/C43H70O15/c1-20(45)54-32-28(48)22(47)18-53-36(32)57-26-10-12-43-19-42(43)14-13-39(6)33(41(8)11-9-27(58-41)38(4,5)52)21(46)16-40(39,7)25(42)15-23(34(43)37(26,2)3)55-35-31(51)30(50)29(49)24(17-44)56-35/h21-36,44,46-52H,9-19H2,1-8H3/t21-,22+,23-,24+,25-,26-,27-,28-,29+,30-,31+,32+,33-,34-,35+,36-,39+,40-,41+,42-,43+/m0/s1

Biological Activity

Astragaloside II can downregulate the expression of the P-gp and mdr1 gene, suppress phosphorylation of extracellular signal regulated kinase 1/2, p38 and c-Jun N-terminal kinase, suggests that Astragaloside II is a potent multidrug resistance (MDR) reversal agent and may be a potential adjunctive agent for hepatic cancer chemotherapy.^[1]

Astragaloside II induces osteogenic activities of osteoblasts through the bone morphogenetic protein-2/MAPK and Smad1/5/8 pathways, it may become a novel candidate that is beneficial for stimulating the osteoblastic activity resulting in bone formation.^[2]

Astragaloside II has immunomodulating activity, can trigger T cell activation through regulation of CD45 protein tyrosine phosphatase activity.^[3]

Astragaloside II in conjunction with cisplatin can significant reduce cell viability, and arrest in S phase and increased apoptosis, suggests that astragaloside II can be served as autophagy inhibitor which restores chemosensitivity of anticancer agent cisplatin and enhances tumor cell death.^[4]