Taraxerol

Taraxerol, a triterpenoid compound, has potent anti-inflammatory effects,it downregulates the expression of proinflammatory mediators in macrophages by interfering with the activation of TAK1 and Akt, thus preventing NF-κB activation. ^[1]

Taraxerol can produce triterpenoid anti-cancer compound in Agrobacterium-transformed root cultures of butterfly pea (Clitoria ternatea L.).^[2]

Taraxerol can be used as a lipid biomarker for mangrove input to the SE Atlantic, the proxy-environment relations for taraxerol and Rhizophora pollen down-core show that increased taraxerol and Rhizophora pollen abundances occur during transgressions and periods with a humid climate, these environmental changes modify the coastal erosion and sedimentation patterns, enhancing the extent of the mangrove ecosystem and/or the transport of mangrove organic matter offshore.^[3]

Taraxerol has inhibitory effects on AGS cell growth through inducing G2/M arrest and promotion of cell apoptosis, taraxeryl acetate has less effect on cell cycle arrest and apoptosis of AGS cells than taraxerol.^[4]

[1] Yao X, Li G, Bai Q, et al. Int Immunopharmacol, 2013, 15(2):316–24.

[2] Swain S S, Rout K K, Chand P K. Appl Biochem Biotech, 2012, 168(3):487-503.

[3] Versteegh G J M, Schefuß E, Dupont L, et al. Geochim Cosmochim Ac, 2004, 68(3):411-22.

[4] Tan B, Shi H L, Ji G, et al. Journal of Chinese Integrative Medicine, 2011, 32(6):1278-84.

[5] Kumar V, Mukherjee K, Kumar S, et al. Phytochem Anal, 2008, 19(19):244-50.