Natural Products
(+)-Lyoniresinol
| Catalog No. | CFN99488 |  |
| CAS No. | 14464-90-5 | |
| Molecular Weight: | 420.5 | |
| Molecular Formula | C22H28O8 | |
| DBs | [PubChem]:274950665 [ChEMBL]:68168 [PCIDB]:7205 |
Standard InChI:
InChI=1S/C22H28O8/c1-27-15-7-12(8-16(28-2)20(15)25)18-14(10-24)13(9-23)5-11-6-17(29-3)21(26)22(30-4)19(11)18/h6-8,13-14,18,23-26H,5,9-10H2,1-4H3/t13-,14-,18+/m0/s1
Biological Activity
Lyoniresinol is one of the eight lignans purified from methanol extract of Vitex negundo and has robust tyrosinase inhibitory capacity, it decreases tyrosinase activity and melanin biosynthesis in B16F10 cells by activating ERK signaling, which downregulates MITF, tyrosinase, but not TRP-1 and TRP-2 protein expression, it can perhaps be incorporated into clinical dermatologic use as a skin lightening agent. [1]
Lyoniresinol has antioxidative activity of pickled ume.[2]
Product
Official website: (+)-Lyoniresinol
Japanese website: (+)-Lyoniresinol
Chinese website: (+)-Lyoniresinol
Japanese website: (+)-Lyoniresinol
Chinese website: (+)-Lyoniresinol
References
[1] Liu H, Sui X, Li X, et al. Mol Cell Biochem, 2013, 373(1-2):211-6.
[2] Shirasaka N, Takasaki R, Yoshizumi H. West African J Med, 1994, 13(1):495-8.
[3] Chen Z Y, Ji-Jun W U, Liu X M, et al. Food Sci, 2009, 30(15):82-5.
Product Use Citation
