Natural Products
Procyanidin B3
| Catalog No. | CFN99559 |  |
| CAS No. | 23567-23-9 | |
| Molecular Weight: | 578.52 | |
| Molecular Formula | C30H26O12 | |
| DBs | [PubChem]:274950594 [ChEMBL]:75630 [PCIDB]:9071 |
Standard InChI:
InChI=1S/C30H26O12/c31-13-7-20(37)24-23(8-13)41-29(12-2-4-16(33)19(36)6-12)27(40)26(24)25-21(38)10-17(34)14-9-22(39)28(42-30(14)25)11-1-3-15(32)18(35)5-11/h1-8,10,22,26-29,31-40H,9H2/t22-,26-,27-,28+,29+/m0/s1
Biological Activity
Procyanidin B3 (B3) prevents osteoarthritis (OA) progression and heterotopic cartilage formation, at least in a part through the suppression of iNOS, these results support the potential therapeutic benefits of B3 for treatment of human OA and heterotopic ossification.[1]
Procyanidin B3 is an inhibitor of histone acetyltransferase, B3 enhances the action of antagonist for prostate cancer cells via inhibition of p300-dependent acetylation of androgen receptor; B3 treatment inhibited acetylation-dependent prostate cell proliferation and expression of cell-cycle control genes, subsequently increasing cell death, indicating the functional importance of AR acetylation for prostate cancer cell growth.[2]
Product
References
[1] Aini H, Ochi H, Iwata M, et al. Plos One, 2012, 7(5):e37728.
[2] Choi K C, Park S, Lim B J, et al. Biochem J, 2011, 433(1):235-44.
[3] Ricardo-Da-Silva J M, Bourzeix M, Cheynier V, et al. Vitis -Geilweilerhof-, 1991, 30(3):245-52.
Product Use Citation
