Natural Products
Sennidin A
| Catalog No. | CFN99597 |  |
| CAS No. | 641-12-3 | |
| Molecular Weight: | 538.46 | |
| Molecular Formula | C30H18O10 | |
| DBs | [PubChem]:274950556 [ChEMBL]: [PCIDB]: |
Standard InChI:
InChI=1S/C30H18O10/c31-17-5-1-3-13-21(15-7-11(29(37)38)9-19(33)25(15)27(35)23(13)17)22-14-4-2-6-18(32)24(14)28(36)26-16(22)8-12(30(39)40)10-20(26)34/h1-10,21-22,31-34H,(H,37,38)(H,39,40)/t21-,22-/m1/s1
Biological Activity
010601I-Sennidin A in combination with necrosis inducing drugs/therapies may generate synergetic tumoricidal effects on solid malignancies by means of primary debulking and secondary cleansing process.[1]
Sennidin A stimulates glucose incorporation in the phosphatidylinositol 3-kinase (PI3K)- and Akt-dependent in rat adipocytes, but in the IR/IRS1-independent manner.[2]
Sennidin A, has two hydroxyanthraquinone-like moieties, exerts inhibition on NS3 helicase with IC50 values of 0.8 uM.[3]
Product
References
[1] Ji Y, Jiang C, Zhang X, et al. Oncotarget, 2014, 5(10):2934-46.
[2] Abe D, Saito T, Sekiya K. Life Sci, 2006, 79(11):1027-33.
[3] Furuta A, Tsubuki M, Endoh M, et al. Int J Mol Sci, 2014, 16(8):18439-53.
[4] Sun Y, Li XT, Yu XG,et al. Chinese Journal of Chromatography, 2004, 22(1):48-50.
Product Use Citation
