Natural Products
Isolinderalactone
| Catalog No. | CFN99762 |  |
| CAS No. | 957-66-4 | |
| Molecular Weight: | 244.29 | |
| Molecular Formula | C15H16O3 | |
| DBs | [PubChem]:274951189 [ChEMBL]:69073 [PCIDB]:12041 |
Standard InChI:
InChI=1S/C15H16O3/c1-5-15(4)6-10-11(8(2)7-17-10)13-12(15)9(3)14(16)18-13/h5,7,12-13H,1,3,6H2,2,4H3/t12-,13-,15?/m0/s1
Biological Activity
Isolinderalactone, a kind of sesquiterpenoids compound, was purified from the root of Lindera strychnifolia and Neolitsea daibuensis and shows anti-inflammatory and anticancer capacity, it induces apoptosis in MDA-MB‑231 cells and suppresses STAT3 signaling pathway through regulation of SOCS3 and miR-30c, may become a novel treatment for triple-negative breast cancer in the future.[1]
Isolinderalactone may cause the cell cycle arrest of A549 cells by induction of p21, and induce apoptosis of A549 human non-small-cell lung carcinoma cells through the Fas/sFasL apoptotic system.[2]
Product
Official website: Isolinderalactone
Japanese website: Isolinderalactone
Chinese website: Isolinderalactone
Japanese website: Isolinderalactone
Chinese website: Isolinderalactone
References
[1] Yen M C, Shih Y C, Hsu Y L, et al. Oncol Rep, 2016, 35(3):1356-64.
[2] Chang W A, Lin E S, Tsai M J, et al. Mol Med Rep, 2014, 9(5):1653-9.
[3] Shu J N, Ouyang R. Chinese Journal of Modern Drug Application, 2009, 3(8):7-8.
Product Use Citation
