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  • Asperosaponin VI

    Catalog No. CFN99766
    CAS No. 39524-08-8
    Molecular Weight: 929.10
    Molecular Formula C47H76O18
    DBs [PubChem]:274951185
    [ChEMBL]:
    [PCIDB]:

    Standard InChI:

    InChI=1S/C47H76O18/c1-42(2)13-15-47(41(59)65-40-37(58)34(55)32(53)26(63-40)20-61-38-36(57)33(54)31(52)25(18-48)62-38)16-14-45(5)22(23(47)17-42)7-8-28-43(3)11-10-29(64-39-35(56)30(51)24(50)19-60-39)44(4,21-49)27(43)9-12-46(28,45)6/h7,23-40,48-58H,8-21H2,1-6H3/t23-,24-,25+,26+,27+,28+,29-,30-,31+,32+,33-,34-,35+,36+,37+,38+,39-,40-,43-,44-,45+,46+,47-/m0/s1

    Biological Activity

    Asperosaponin VI (ASA VI) is a kind of saponin in the medicinal herb Dipsacus asper Wall which has long been used as an antiosteoporosis drug, exhibits a significant induction of proliferation, differentiation and mineralization in MC3T3-E1 and primary osteoblastic cells, it may induce osteoblast maturation and differentiation, and then increase bone formation via increasing BMP-2 synthesis, and activating p38 and ERK1/2.[1]
    Asperosaponin VI, a triterpene saponin isolated from Dipsacus asper Wall, plays protective roles on acute myocardial infarction in rats.[2]
    Asperosaponin VI has protective effect against hypoxia-induced cardiomyocytes apoptosis probably by activating the PI3K/Akt and CREB pathways.[3]

    Product

    Official website: Asperosaponin VI
    Japanese website: Asperosaponin VI
    Chinese website: Asperosaponin VI

    References

    [1] Yinbo Niu †, Yuhua Li †, Huang H, et al. Phytothe Res , 2011, 25(11):1700-6.
    [2] Li C, Liu Z J, Li G, et al. Eur J Pharmacol, 2010, 217(Pt 23):4123-31.
    [3] Li C, Tian J, Li G, et al. Eur J Pharmacol, 2010, 649(1-3):100-7.
    [4] Shan X, Wang J, Wu A. China Pharmacist, 2013, 16(03):388-90.

    Product Use Citation