Natural Products
Sesamolin
| Catalog No. | CFN99799 |  |
| CAS No. | 526-07-8 | |
| Molecular Weight: | 370.36 | |
| Molecular Formula | C20H18O7 | |
| DBs | [PubChem]:274951155 [ChEMBL]:9127 [PCIDB]: |
Standard InChI:
InChI=1S/C20H18O7/c1-3-15-17(25-9-23-15)5-11(1)19-13-7-22-20(14(13)8-21-19)27-12-2-4-16-18(6-12)26-10-24-16/h1-6,13-14,19-20H,7-10H2/t13-,14-,19+,20+/m0/s1
Biological Activity
Sesaminol possesses antioxidative activity, can inhibit lipid peroxidation in rat liver and kidney.[1]
Sesamolin has protective effect on hypoxic neuronal and PC12 cells, it might be related to suppression of ROS generation and MAPK activation.[2]
Sesamolin can inhibit proliferation by inducing apoptosis in human lymphoid leukemia Molt 4B cells. [3]
Sesamolin has protective effects on murine BV-2 microglia cell line under hypoxia, the mechanism involves inhibition of MAPK pathways and apoptosis through scavenging of ROS in hypoxia-stressed BV-2 cells.[4]
Sesamolin exerts effective neuroprotection against cerbral ischemia.[5]
Product
References
[1] Kang M H, Naito M, Tsujihara N, et al. J Nut, 1998, 128(6):1018-22.
[2] Hou C W, Huang H M, Tzen J T C, et al. J Neurosci Res, 2003, 74(1):123–33.
[3] Miyahara Y, Hibasami H, Katsuzaki H, et al. Int J Mol Med, 2001, 7(7):369-71.
[4] Hou C W, Wu C C, Yang C H, et al. Neurosci Lett, 2004, 367(1):10-3.
[5] Cheng F C, Jinn T R, Hou R C W, et al. Int J Biomed Sci Ljbs, 2006, 2(3):284-8.
[6] Huang J. Journal of the Chinese Cereals & Oils Association, 2011, 26(01):120-3.
Product Use Citation
