Natural Products
Ganoderic acid DM
| Catalog No. | CFN99815 |  |
| CAS No. | 173075-45-1 | |
| Molecular Weight: | 468.7 | |
| Molecular Formula | C30H44O4 | |
| DBs | [PubChem]:274951139 [ChEMBL]: [PCIDB]:45319 |
Standard InChI:
InChI=1S/C30H44O4/c1-18(9-8-10-19(2)26(33)34)20-11-16-30(7)25-21(12-15-29(20,30)6)28(5)14-13-24(32)27(3,4)23(28)17-22(25)31/h10,18,20,23H,8-9,11-17H2,1-7H3,(H,33,34)/b19-10+/t18-,20-,23+,28-,29-,30+/m1/s1
Biological Activity
Ganoderic acid DM (GADM) is a triterpenoid isolated from Ganoderma lucidum, a well-known edible medicinal mushroom, it effectively inhibits cell proliferation and colony formation in MCF-7 human breast cancer cells, which is much stronger than that of MDA-MB-231 breast cancer cells. [1]
Ganoderic Acid DM is an antiandrogenic osteoclastogenesis inhibitor.[2]
Ganoderic acid DM especially suppresses the expression of c-Fos and nuclear factor of activated T cells c1 (NFATc1), this suppression leads to the inhibition of dendritic cell-specific transmembrane protein (DC-STAMP) expression and reduces osteoclast fusion.[3]
Ganoderic acid DM (GA-DM) has shown toxicity to both androgen-dependent and independent prostate cancer cells with reduced osteoclastogenesis in late stage metastatic disease, it may an alternative agent for the treatment of advanced prostate cancer.[4]
Product
Official website: Ganoderic acid DM
Japanese website: Ganoderic acid DM
Chinese website: Ganoderic acid DM
Japanese website: Ganoderic acid DM
Chinese website: Ganoderic acid DM
References
[1] Wu G S, Lu J J, Guo J J, et al. Fitoterapia, 2012, 83(2):408-14.
[2] Liu J, Shiono J, Shimizu K, et al. Bioorg Med Chem Lett, 2009, 19(19):2154-7.
[3] Miyamoto I, Liu J, Shimizu K, et al. Eur J Pharmacol, 2009, 602(1):1-7.
[4] Morris J B. Open Prostate Cancer J, 2010, 3(3):78-85.
[5] Li B M, Gu H F, Li H, et al. Trad Chinese Med, 2012, 37 (23): 3599-603.
Product Use Citation
