• ChemFaces is a professional high-purity natural products manufacturer.
  • Product Intended Use
  • 1. Reference standards
  • 2. Pharmacological research
  • 3. Inhibitors
  • Home
  • Biologically Active
  • Hot Products
  • Plant Catalog
  • Products
  • Customer Support
  • Product Use Citation
  • About Us
  • Contact Us
  • Hydroxysafflor yellow A

    Catalog No. CFN99950
    CAS No. 78281-02-4
    Molecular Weight: 612.53
    Molecular Formula C27H32O16
    DBs [PubChem]:274951004

    Standard InChI:


    Biological Activity

    Hydroxysafflor yellow A (HSYA), isolated from the dried flower of Carthamus tinctorius L. , which is extensively used in traditional Chinese medicine to treat cirrhosis, can protect against chronic carbon tetrachloride-induced liver fibrosis, might be a promising antifibrotic agent in chronic liver disease.[1]
    Hydroxysafflor yellow A can provide protection to H9c2 cardiomyocytes against A/R-induced apoptosis, and this protective effect largely depends on the upregulation of HO-1 expression through the PI3K/Akt/Nrf2 signaling pathway.[2]
    Hydroxysafflor yellow A may provide neuroprotection against cerebral ischemia/
    reperfusion injury through its suppression of inflammatory responses following focal ischemia reperfusion, and its antioxidant action by inhibiting the opening of mtPTP by a free radical scavenging action in the brain.[3-5]
    Hydroxysafflor yellow A could enhance the survival of ECs under hypoxia, which may be correlated with its effect of upregulating the bcl-2/bax ratio and promoting HIF-1 alpha protein accumulation, which increases VEGF, these findings provide evidence for the mechanisms by which HSYA maintains EC survival under hypoxia.[6]
    Hydroxysafflor yellow A suppresses inflammatory responses of BV2 microglia after oxygen-glucose deprivation, which is probably associated with the inhibition of the NF-κB signaling pathway and phosphorylation of p38.[7]


    Official website: Hydroxysafflor yellow A
    Japanese website: Hydroxysafflor yellow A
    Chinese website: Hydroxysafflor yellow A


    [1] Zhang Y, Guo J, Dong H, et al. Eur J Pharmacol, 2011, 660(2–3):438-44.
    [2] Liu S X, Zhang Y, Wang Y F, et al. Int J Cardiol, 2012, 160(2):95-101.
    [3] Wei X, Liu H, Sun X, et al. Neurosci Lett, 2005, 386(1):58-62.
    [4] Tian J, Li G, Liu Z, et al. Pharmacology, 2008, 82(2):121-6.
    [5] Ye S Y, Gao W Y. Arch Pharml Res, 2008, 31(8):1010-5.
    [6] Ji D B, Zhu M C, Zhu B, et al. J Cardiovasc Pharm, 2008, 52(2):191-202.
    [7] Li J. Neurosci Lett, 2013, 535(1):51-6.
    [8]Tan S J, Chi J P, He Y Q, et al. Pharm J Chinese Peoples Liberation Army,  2013(05):464-5.

    Product Use Citation