• ChemFaces is a professional high-purity natural products manufacturer.
  • Product Intended Use
  • 1. Reference standards
  • 2. Pharmacological research
  • 3. Inhibitors
  • Home
  • Biologically Active
  • Hot Products
  • Plant Catalog
  • Products
  • Customer Support
  • Product Use Citation
  • About Us
  • Contact Us
  • Ginsenoside Rg1

    Catalog No. CFN99967
    CAS No. 22427-39-0
    Molecular Weight: 801.01
    Molecular Formula C42H72O14
    DBs [PubChem]:11138
    [ChEMBL]:67987
    [PCIDB]:3520

    Standard InChI:

    InChI=1S/C42H72O14/c1-20(2)10-9-13-42(8,56-37-34(52)32(50)30(48)25(19-44)55-37)21-11-15-40(6)28(21)22(45)16-26-39(5)14-12-27(46)38(3,4)35(39)23(17-41(26,40)7)53-36-33(51)31(49)29(47)24(18-43)54-36/h10,21-37,43-52H,9,11-19H2,1-8H3/t21-,22+,23-,24?,25?,26+,27-,28-,29+,30+,31?,32-,33?,34?,35-,36+,37-,39+,40+,41+,42-/m0/s1

    Biological Activity

    Ginsenoside Rg1 is the main pharmacologically active compound of ginsenosides and has demonstrated pharmacological effects in the cardiovascular system, central nervous system and immune system; Rg1 has protective effect against Aβ25-35-induced toxicity in PC12 cells,might be through the insulin-like growth factor-I receptor (IGF-IR) and estrogen receptor (ER)signaling pathways.[1]
    Ginsenoside Rg1 is often recommended for its antiaging effects,Rg1 supplementation improved the performance of aged mice in behavior test and significantly upregulated the expression of synaptic plasticity-associated proteins in hippocampus, including synaptophysin, N-methyl-D-aspartate receptor subunit 1, postsynaptic density-95, and calcium/calmodulin-dependent protein kinase II alpha, via promoting mammalian target of rapamycin pathway activation.[2]
    Ginsenoside Rg1 increases the expression of the vascular endothelial growth factor (VEGF) mRNA and reduces expression of transforming growth factor beta (TGF-B) mRNA in wounded skin , suggests that Rg1 should be helpful for the promotion of wound healing.[3]
    Ginsenoside Rg1 is a desirable agent for enhancing CD4+ T-cell activity, as well as the correction of Th1-dominant pathological disorders, which by increasing Th2 specific cytokine secretion and by repressing Th1 specific cytokine production.[4]
    Ginsenoside Rg1 promotes proliferation, migration, adhesion and in vitro vasculogenesis.[5] Rg1 inhibits platelet activation via the inhibition of ERK pathway, and attenuates arterial thrombus formation in vivo.[6]

    Ginsenoside Rg1 possesses the neuroprotective effects on inducing differentiation of ES cells into neurons in vitro via the GR-MEK-/2-K-signaling pathway.[7]

    Product

    Official website: Ginsenoside Rg1
    Japanese website: Ginsenoside Rg1
    Chinese website: Ginsenoside Rg1

    References

    [1] Chen W F, Zhou L P, Chen L, et al. Neurochem Int, 2013, 62(8):1065-71.
    [2] Yang L, Zhang J, Zheng K, et al. Journals of Gerontology, 2014, 69(3):282-94.
    [3] 임애경, 김길수, 박수정, et al. 한국식품영양과학회지, 2010, 39(10):437-45.
    [4] Lee E J, Ko E, Lee J, et al. Int Immunopharmaco, 2004, 4(4):235-44.
    [5] Shi A W, Wang X B, Lu F X, et al. Acta Phamacol Sin, 2009, 30(3):299-306.
    [6] Zhou Q, Jiang L, Xu C, et al. Thromb Res , 2014, 133(1):57-65.
    [7] Wu J, Pan Z, Cheng M, et al. Neurochem Int , 2012, 62(1):92-102.
    [8] Jia G, Li M A, Han F. Journal of Tianjin University of Traditional Chinese Medicine, 2011(1):41-42.
    Product Use Citation