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  • Ginsenoside Re

    Catalog No. CFN99974
    CAS No. 52286-59-6
    Molecular Weight: 947.15
    Molecular Formula C48H82O18
    DBs [PubChem]:77148
    [ChEMBL]:11136
    [PCIDB]:3518

    Standard InChI:

    InChI=1S/C48H82O18/c1-21(2)11-10-14-48(9,66-42-38(60)35(57)32(54)26(19-49)63-42)23-12-16-46(7)30(23)24(51)17-28-45(6)15-13-29(52)44(4,5)40(45)25(18-47(28,46)8)62-43-39(36(58)33(55)27(20-50)64-43)65-41-37(59)34(56)31(53)22(3)61-41/h11,22-43,49-60H,10,12-20H2,1-9H3/t22?,23-,24+,25-,26?,27?,28+,29-,30-,31-,32+,33+,34-,35-,36?,37?,38?,39?,40-,41-,42-,43+,45+,46+,47+,48-/m0/s1

    Biological Activity

    Ginsenoside Re, a main phytosterol of Panax ginseng, inhibits Ca(2+) accumulation in mitochondria during cardiac ischemia/reperfusion, which is attributable to nitric oxide (NO)-induced Ca(2+) channel inhibition and K(+) channel activation in cardiac myocytes, acts as a specific agonist for the nongenomic pathway of sex steroid receptors, and NO released from activated eNOS underlies cardiac K(+) channel activation and protection against ischemia-reperfusion injury, G-Re also exerts antiischemic effect and induces angiogenic regeneration.[1,2]
    Ginsenoside Re has anti-diabetic and anti-hyperlipidemic activities ,can improve hyperglycemia and hyperlipidemia through activation of AMPK, and confer beneficial effects on type 2 diabetic patients with insulin resistance and dyslipidemia. [3]
    Ginsenoside Re can improve the cognition of streptozotocin-induced diabetic rats,the mechanism is by its anti-inflammation and antioxidation; glycemic control benefits the attenuation of diabetes-associated cognitive decline.[4]
    Ginsenoside Re can hyperpolarize HCAECs,and this effect can be reversed by apamin, suggests ginsenoside Re increases HCAEC outward current via SKCa channel activation, and NSC channel is not involved.[5]
    Ginsenoside Re increases the proliferation of CD4 + T cells with decreases cell death, and enhances viability of CD4 + T cells through the regulation of IFN-γ-dependent autophagy activity.[6]

    Ginsenoside Re exhibits potent neuroprotective effects against neuroinflammation in a murine model of ALS, ginsenoside Re treatment can reduce the loss of motor neurons and active-microglia-related expression of Iba-1 in the spinal cord of symptom.[7]

    Product

    Official website: Ginsenoside Re
    Japanese website: Ginsenoside Re
    Chinese website: Ginsenoside Re

    References

    [1] Furukawa T, Bai C X, Kaihara A, et al. Mol  Pharmacol, 2006, 70(6):1916-24.
    [2] Peng L, Sun S, Xie L H, et al. Cardiovasc Ther , 2012, 30(4):e183–e188.
    [3] Quan H Y, Yuan H D, Jung M S, et al. Int J of Mol Med, 2012, 29(1):73-80.
    [4] Liu Y W, Zhu X, Li W, et al. Pharmacol Biochem, 2012, 101(1):93-98.
    [5] Sukrittanon S, Watanapa W B, Ruamyod K. Life Sci, 2014, 115(1–2):15-21.
    [6] Son Y M, Kwak C W, Lee Y J, et al. Int Immunopharmaco, 2010, 10(5):626-631.
    [7] Cai M, Yang E J. Am J Chinese Med, 2016, 44(2):401-413.
    [8] Huang X, Liang T. Chinese Medicine Modern Distance Education of China, 2011, 09(21):131-132.

    Product Use Citation