Ginsenoside Rf

GinsenosideRf, as an effective natural product, induces G2/Mphase cell cycle arrest and apoptosis in human osteosarcoma MG-63 cells through the mitochondrial pathway, suggests that it may have a therapeutic effect on human osteosarcoma.^[1]

Ginsenoside Rf(Rf) , a trace component of ginseng root, produces antinociception in mice; Ginsenoside Rf potentiates U-50,488H-induced analgesia and inhibits tolerance to its analgesia in mice.^[2,3]

Ginsenoside Rf regulates voltage-dependent Ca(2+) channels through pertussis toxin (PTX)-sensitive G proteins in rat sensory neurons, suggests that Rf can act through a novel G protein-linked receptor in the nervous system. ^[4]

Ginsenoside Rf induces CYP3A4 and MDR1 gene expression through constitutive androstane receptor- and pregnane X receptor-mediated pathways. ^[5]

Ginsenoside Rf significantly reduces the production of IL-1β, IL-6, TNF-α, NO, and ROS, which are most highly activated in inflammatory bowel disease (IBD), and suppresses TNF-α/LPS-induced NF-κB transcriptional activity; suggests that ginsenoside Rf has potent intestinal anti-inflammatory effects that could be used to treat diseases such as IBD.^[6]

[1] Shangguan W J, Li H, Zhang Y H. Oncol Rep, 2014, 31(1):305-13.

[2] Mogil J S, Shin Y H, Mccleskey E W, et al. Brain Res, 1998, 792(2):218-28.

[3] Nemmani K V S, Ramarao P. Life Sci, 2003, 72(7):759-68.

[4] Choi S, Jung S Y, Ko Y S, et al. Mol Pharmacol, 2002, 61(4):928-35.

[5] Li Y, Wang Q, Yao X, et al. Eur J Pharmacol, 2010, 640(1-3):46-54.

[6] Ahn S, Siddiqi M H, Aceituno V C, et al. Immunl Invest, 2016,45(5):439-49.

[7] Zang P, Zhang P, Gao Y, et al. J Med Plant Res, 2011, 5(23):5513-6.