Natural Products
Saikosaponin C
| Catalog No. | CFN99988 |  |
| CAS No. | 20736-08-7 | |
| Molecular Weight: | 927.14 | |
| Molecular Formula | C48H72O17 | |
| DBs | [PubChem]:274950966 [ChEMBL]: [PCIDB]:40181 |
Standard InChI:
InChI=1S/C48H78O17/c1-22-30(51)32(53)36(57)40(61-22)65-38-24(20-59-39-35(56)33(54)31(52)23(19-49)62-39)63-41(37(58)34(38)55)64-29-11-12-44(6)25(43(29,4)5)9-13-45(7)26(44)10-14-48-27-17-42(2,3)15-16-47(27,21-60-48)28(50)18-46(45,48)8/h10,14,22-41,49-58H,9,11-13,15-21H2,1-8H3/t22-,23+,24+,25-,26+,27+,28-,29-,30-,31+,32+,33-,34+,35+,36+,37+,38+,39+,40-,41-,44-,45+,46-,47+,48-/m0/s1
Biological Activity
Saikosaponin C (SSC) is one of the saikosaponins that are consisted in a Chinese herb, Radix Bupleuri, it yields a potent effect on inducing human umbilical vein endothelial cells (HUVECs) viability and growth, also induces endothelial cells migration and capillary tube formation. [1]
Saikosaponin C can inhibit lipopolysaccharide-induced apoptosis by suppressing caspase-3 activation and subsequent degradation of focal adhesion kinase in human umbilical vein endothelial cells.[2]
Saikosaponin C seems to have beneficial effects on cellular tau function, it accelerates nerve growth factor (NGF)-mediated neurite outgrowth and increases the assembly of microtubules (MT) and synaptic marker proteins such as synaptophysin and PSD-95, suggests SSc might be a novel therapeutic tool for treating human AD and other neurodegenerative diseases. [3]
Saikosaponin C can cure liver disease.[4]
Product
References
[1] Shyu K G, Tsai S C, Wang B W, et al. Life Sci, 2004, 76(7):813-26.
[2] Lee T H, Chang J, Kim B M. Biochem Bioph Res Co, 2014, 445(3):615-21.
[3] Tae Ho Lee †, Sung Ha Park †, You M H, et al. J Neurochem, 2015, 136(6):1232-45.
[4] Chen Y C, Wang H M, Niu Q X, et al. Molecules, 2016, 21(2):153.
[5] Wang X D, Zhang Z W, Sun X M, et al. J Pharm Practice, 2001, 19(05):298-300.
Product Use Citation
