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    CAS No. 345287-92-5 Price
    Catalog No.CFN96911Purity>=98%
    Molecular Weight304.25Type of CompoundXanthones
    FormulaC15H12O7Physical DescriptionPowder
    Download     COA    MSDSSimilar structuralComparison (Web)
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    Biological Activity
    Description: 1,3,6-Trihydroxy-2,5-dimethoxyxanthone may have antifungal activity. It also shows antimutagenic potential, in particular preventing mutations caused by aflatoxin B1 (AFB1) and benzo[a]pyrene (B[a]P).
    Targets: Antifection
    In vitro:
    Steroids. 2013 Nov;78(11):1053-63.
    Estrogenic and chemopreventive activities of xanthones and flavones of Syngonanthus (Eriocaulaceae).[Pubmed: 23891669]

    We used recombinant yeast assay (RYA), with the strain BY4741 of Saccharomyces cerevisiae, and Ames test, with strains TA100, TA98, TA97a and TA102 of Salmonella typhimirium, to evaluate estrogenicity, mutagenicity and antimutagenicity of methanolic extracts of Syngonanthus dealbatus (S.d.), Syngonanthus macrolepsis (S.m.), Syngonanthus nitens (S.n.) and Syngonanthus suberosus (S.s.), and of 9 compounds isolated from them (1=luteolin, 2=mix of A-1,3,6-trihydroxy-2-methoxyxanthone and B-1,3,6-Trihydroxy-2,5-dimethoxyxanthone, 3=1,5,7-trihydroxy-3,6-dimethoxyxanthone, 4=1,3,6,8-tetrahydroxy-2,5-dimethoxyxanthone, 5=1,3,6,8-tetrahydroxy-5-methoxyxanthone, 6=7-methoxyluteolin-8-C-β-glucopyranoside, 7=7-methoxyluteolin-6-C-β-glucopyranoside, 8=7,3'-dimethoxyluteolin-6-C-β-glucopyranoside and 9=6-hydroxyluteolin). The results indicated the estrogenic potential of the S. nitens methanol extract and four of its isolated xanthones, which exhibited, respectively, 14.74±1.63 nM; 19.54±6.61; 7.20±0.37; 6.71±1.02 e 10.01±4.26 nM of estradiol-equivalents (EEQ). None of the extracts or isolated compounds showed mutagenicity in any of the test strains and all of them showed antimutagenic potential, in particular preventing mutations caused by aflatoxin B1 (AFB1) and benzo[a]pyrene (B[a]P).
    The results show that the xanthones, only isolated from the methanol extract of S. nitens capitula, probably were the responsible for its estrogenic activity and could be useful as phytoestrogens, providing a new opportunity to develop hormonal agents. In addition, flavones and xanthones could also be used as a new antimutagenic agent. Since, the mutagens are involved in the initiation and promotion of several human diseases, including cancer, the significance of novel bioactive phytocompounds in counteracting these pro-mutagenic and carcinogenic effects is now gaining credence.
    1,3,6-Trihydroxy-2,5-dimethoxyxanthone Description
    Source: The aerial parts of Monnina obtusifolia.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.2868 mL 16.4339 mL 32.8677 mL 65.7354 mL 82.1693 mL
    5 mM 0.6574 mL 3.2868 mL 6.5735 mL 13.1471 mL 16.4339 mL
    10 mM 0.3287 mL 1.6434 mL 3.2868 mL 6.5735 mL 8.2169 mL
    50 mM 0.0657 mL 0.3287 mL 0.6574 mL 1.3147 mL 1.6434 mL
    100 mM 0.0329 mL 0.1643 mL 0.3287 mL 0.6574 mL 0.8217 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Structure Identification:
    J Nat Prod. 2004 Sep;67(9):1450-4.
    Lipoxygenase inhibitory constituents from Periploca aphylla.[Pubmed: 15387640]

    Bisflavan-3-ols 1 and 2 and norterpenoid 3 have been isolated from the methanolic extract of the whole plant of Periploca aphylla. Their structures have been assigned on the basis of spectroscopic analysis including 1D and 2D NMR techniques. In addition, o-phthalic acid bis(2-ethylnonyl) ester (4), 1,3,6-Trihydroxy-2,5-dimethoxyxanthone (5), and (+)-lyoniresinol (6) have been reported for the first time from this species.
    Compounds 1-3 displayed evident inhibitory potential against the enzyme lipoxygenase in a concentration-dependent fashion with IC(50) values 19.7, 13.5, and 150.1 microM, respectively.
    Phytochemistry. 1994 Oct;37(3):875-8.
    Xanthone and antifungal constituents from Monnina obtusifolia.[Pubmed: 7765695]

    Three biphenyls and four xanthones have been isolated from the aerial parts of Monnina obtusifolia. The structures were established on the basis of their spectral data and that of some derivatives. The biphenyls have been isolated previously from the same genus. 1,3,6-Trihydroxy-2,5-dimethoxyxanthone is a new natural product, whereas the other xanthones have been described in other species.
    The antifungal activity of the isolated compounds has been determined.