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    Catalog No. CFN99122 Purity >=98% Price $248 / 20mg
    M. F C25H24O12 M. W 516.46
    Physical Description White powder Type of Compound Phenylpropanoids
    Identify | Grade NMR | HPLC Certification ChemFaces was verified by ISO2008:9001 certificate
    Chemical Structure 1,4-Dicaffeoylquinic acid
    Chemical Information Download 1,4-Dicaffeoylquinic acid -SDF
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    Download 1,4-Dicaffeoylquinic acid : Manual    COA    MSDS
    More articles cited ChemFaces products.
  • Ajchem JournalJAN. 2014
  • Phytother Res.2015 Apr 17.
  • Phytomedicine2015 March 20.
  • Journal of Agricultural Science2015 Sep 15
  • Fitoterapia.2015 Jan;100:179-86.
  • Int J Mol Sci.2015 Aug 7;16(8):18396-411.?
  • Ind Crops Prod.2014 Dec 1;62:173-178.
  • Phytochem Anal.2013 Sep-Oct.
  • PhytomedicineFeb. 11. 2016
  • Br J Pharmacol.2016 Jan;173(2):396-410.
  • Acta Pharmaceutica Sinica B2015 Apr.7.
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  • Our products had been exported to the following research institutions and universities, And still growing.
  • National Chung Hsing University (Taiwan)
  • University of Liège (Belgium)
  • VIB Department of Plant Systems Biol... (Belgium)
  • University of South Australia (Australia)
  • Sapienza University of Rome (Italy)
  • Kyushu University (Japan)
  • Georgia Institute of Technology (USA)
  • Universidad Veracuzana (Mexico)
  • Siksha O Anusandhan University (India)
  • University of Helsinki (Finland)
  • Subang Jaya Medical Centre (Malaysia)
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  • 1,4-Dicaffeoylquinic acid Description
    Source: The flowerbud of Lonicera japonica Thunb.
    Biological Activity
    or Inhibitors:
    1. 1,4-Dicaffeoylquinic acid has antioxidant activity.
    2. 1,4-Dicaffeoylquinic acid is a potent and highly selective class of HIV-1 integrase inhibitors, inhibitsHIV-1 replication in MT-2 cell culture at non-toxic concentrations.
    Solvent: Pyridine, Methanol, Ethanol, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Whenever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.9363 mL 9.6813 mL 19.3626 mL 38.7252 mL 48.4065 mL
    5 mM 0.3873 mL 1.9363 mL 3.8725 mL 7.745 mL 9.6813 mL
    10 mM 0.1936 mL 0.9681 mL 1.9363 mL 3.8725 mL 4.8406 mL
    50 mM 0.0387 mL 0.1936 mL 0.3873 mL 0.7745 mL 0.9681 mL
    100 mM 0.0194 mL 0.0968 mL 0.1936 mL 0.3873 mL 0.4841 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better
                 solubility within lower of Concentrations.
    1,4-Dicaffeoylquinic acid References Information
    Citation [1]

    Chin J Nat Med. 2014 Feb;12(2):131-8.

    Inhibitory effect of medicinal plant-derived carboxylic acids on the human transporters hOAT1, hOAT3, hOATP1B1, and hOATP2B1.[Pubmed: 24636064]
    In this study, uptake experiments were performed to assess the inhibitory effects of cinnamic acid, ferulic acid, oleanolic acid, deoxycholic acid, and cynarin(1,4-Dicaffeoylquinic acid ) on hOAT1, hOAT3, hOATP1B1, and hOATP2B1. After a drug-drug interaction (DDI) investigation, cinnamic acid, ferulic acid, deoxycholic acid, and cynarin(1,4-Dicaffeoylquinic acid ) were found and validated to inhibit hOAT1 in a competitive manner, and deoxycholic acid was found to be an inhibitor of all four transporters. The apparent 50% inhibitory concentrations of cinnamic acid, ferulic acid, deoxycholic acid, and cynarin(1,4-Dicaffeoylquinic acid ) were estimated to be 133.87, 3.69, 90.03 and 6.03 μmol·L(-1) for hOAT1, respectively. The apparent 50% inhibitory concentrations of deoxycholic acid were estimated to be 9.57 μmol·L(-1) for hOAT3, 70.54 μmol·L(-1) for hOATP1B1, and 168.27 μmol·L(-1) for hOATP2B1. Because cinnamic acid, ferulic acid, and cynarin are ingredients of food or food additives, the present study suggests there are new food-drug interactions to be disclosed.