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    Catalog No. CFN99132 Purity >=98% Price $248 / 20mg
    M. F C21H34O4 M. W 350.49
    Physical Description Powder Type of Compound Phenols
    Identify | Grade NMR | HPLC Certification ChemFaces was verified by ISO2008:9001 certificate
    Chemical Structure 10-Gingerol
    Chemical Information Download 10-Gingerol-SDF
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    More articles cited ChemFaces products.
  • BMC Complement Altern Med.2014 Jul 14;14:242.
  • British Jou. Med. & Med. Research2014 Jan 1
  • Int J Mol Sci.2015 Aug 7;16(8):18396-411.?
  • J Chromatogr Sci.2015 Feb 5. pii: bmu231.
  • Acta Agriculturae ScandinavicaJan. 18, 2016
  • J. of Pha. and Biomed. Analysis25 Jan. 2016
  • Evid Based Complement Alternat Med. 2016 May 24;
  • Molecules.2013 Nov 14;18(11):14105-21.
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  • Our products had been exported to the following research institutions and universities, And still growing.
  • Celltrion Chemical Research Institute (Korea)
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  • Universidad Miguel Hernández (Spain)
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  • University of Beira Interior (Portugal)
  • Regional Crop Research Institute (Korea)
  • Kazusa DNA Research Institute (Japan)
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  • 10-Gingerol Description
    Source: The rhizomes of Zingiber officinale Roscoe.
    Biological Activity
    or Inhibitors:
    1. 10-Gingerol has anti-neuroinflammatory capacity.
    2. 10-Gingerol effectively inhibits the growth of the oral pathogens, and inhibits exogenous ghrelin deacylation.
    3. 10-Gingerol induces [Ca2+]i rise by causing Ca2+ release from the endoplasmic reticulum and Ca2+ influx from non-L-type Ca2+ channels in SW480 cancer cells.
    4. 10-Gingerol-induced apoptosis was accompanied by phosphorylation of the mitogen-activated protein kinase (MAPKs) family, c-Jun N-terminal kinase (JNK), p38 MAPK (p38), and extracellular signal-regulated kinase (ERK).
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Whenever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.8531 mL 14.2657 mL 28.5315 mL 57.063 mL 71.3287 mL
    5 mM 0.5706 mL 2.8531 mL 5.7063 mL 11.4126 mL 14.2657 mL
    10 mM 0.2853 mL 1.4266 mL 2.8531 mL 5.7063 mL 7.1329 mL
    50 mM 0.0571 mL 0.2853 mL 0.5706 mL 1.1413 mL 1.4266 mL
    100 mM 0.0285 mL 0.1427 mL 0.2853 mL 0.5706 mL 0.7133 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better
                 solubility within lower of Concentrations.
    10-Gingerol References Information
    Citation [1]

    In Vitro Cell Dev Biol Anim. 2015 Jan;51(1):92-101.

    10-Gingerol induces mitochondrial apoptosis through activation of MAPK pathway in HCT116 human colon cancer cells.[Pubmed: 25148824]
    10-Gingerol inhibited the proliferation of HCT116 cells by 50% at a concentration of 30 μM, and this inhibition was dose-dependent accompanied by the morphological changes indicative of apoptosis. Furthermore, flow cytometric analysis showed that 10-Gingerol increased DNA in the sub-G1 phase of the cell cycle, and the extent of apoptosis was confirmed by Annexin V and PI double staining. Analysis of the mechanism of these events indicated that 10-Gingerol -treated cells exhibited an increased ratio of Bax/Bcl-2, resulting in the activation of caspase-9, caspase-3, and poly-ADP-ribose polymerase in a dose-dependent manner, which are hallmarks of apoptosis. Moreover, 10-Gingerol-induced apoptosis was accompanied by phosphorylation of the mitogen-activated protein kinase (MAPKs) family, c-Jun N-terminal kinase (JNK), p38 MAPK (p38), and extracellular signal-regulated kinase (ERK).
    Citation [2]

    Food Chem. 2013 Dec 1;141(3):3183-91.

    Anti-neuroinflammatory capacity of fresh ginger is attributed mainly to 10-gingerol.[Pubmed: 23871076]
    Despite the anti-neuroinflammatory capacity of ginger, the corresponding active constituents are unclear. This study analyzed the composition of fresh ginger ethanolic extract by using LC-MS. Inhibitory activities of fresh ginger extract and seven gingerol-related compounds on the neuro-inflammation were also evaluated by using a lipopolysaccharide (LPS)-activated BV2 microglia culture model. Except for zingerone and 6-gingerol, other gingerols and shogaols at a concentration of 20 μM inhibited the production of nitric oxide, IL-1β, IL-6 and TNF-α as well as their mRNA levels in LPS-activated BV2 microglia. Blocking NF-κB activation was the underlying mechanism responsible for inhibiting the proinflammatory gene expression. Increasing the alkyl chain length enhanced the anti-neuroinflammatory capacity of gingerols yet, conversely, attenuated those of shogaols. 6-Gingerol was the most abundant compound in the fresh ginger extract, followed by 10-Gingerol. Furthermore, fresh ginger extract exhibited a significant anti-neuroinflammatory capacity, which was largely owing to 10-Gingerol, but not 6-gingerol.
    Citation [3]

    Biochem Biophys Res Commun. 2011 Sep 2;412(3):506-11.

    10-Gingerol, a component of rikkunshito, improves cisplatin-induced anorexia by inhibiting acylated ghrelin degradation.[Pubmed: 21846463]
    Rikkunshito (RKT), a Japanese traditional medicine, has been shown to stimulate food intake in rats with cisplatin-induced anorexia; however, the underlying mechanisms remain unknown. In this study, we investigated whether RKT is involved in the degradation of peripheral ghrelin. RKT inhibited decreases in plasma ghrelin level and enhanced acyl- to desacyl-ghrelin (A/D) ratio in cisplatin-treated rats. Several components of RKT demonstrated inhibitory activity against ghrelin deacylating enzymes. In addition, 10-Gingerol, a component of RKT, inhibited exogenous ghrelin deacylation. Therefore, RKT may enhance plasma acyl-ghrelin level, at least in part, by inhibiting the circulating ghrelin degrading enzyme.