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    11-O-Galloylbergenin
    11-O-Galloylbergenin
    Information
    CAS No. 82958-44-9 Price
    Catalog No.CFN96345Purity>=98%
    Molecular Weight480.4Type of CompoundPhenols
    FormulaC21H20O13Physical DescriptionPowder
    Download     COA    MSDSSimilar structuralComparison (Web)
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    11-O-Galloylbergenin Description
    Source: The aerial parts of Bergenia ligulata.
    Biological Activity or Inhibitors: 1. 11-O-Galloylbergenin shows significant analgesic activity at doses of 20 and 40 mg/kg against formalin test in rats, and it exhibits significant anti-inflammatory activity in carrageenan-induced paw edema model at doses of 10, 20 and 30 mg/kg.
    2. 11-O-Galloylbergenin shows good antioxidant and antiplasmodial activities, the EC50 values are 7.45±0.2 ug/mL and 5.39±0.28 ug/mL in DPPH antioxidant assay and reducing power assay respectively, while IC50 value for antiplasmodial assay is less than 2.5 uM.
    3. 11-O-Galloylbergenin shows significant urease inhibitory potential with IC50 value of 38.6±1.5 uM.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.0816 mL 10.408 mL 20.816 mL 41.632 mL 52.04 mL
    5 mM 0.4163 mL 2.0816 mL 4.1632 mL 8.3264 mL 10.408 mL
    10 mM 0.2082 mL 1.0408 mL 2.0816 mL 4.1632 mL 5.204 mL
    50 mM 0.0416 mL 0.2082 mL 0.4163 mL 0.8326 mL 1.0408 mL
    100 mM 0.0208 mL 0.1041 mL 0.2082 mL 0.4163 mL 0.5204 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    11-O-Galloylbergenin References Information
    Citation [1]

    J Ethnopharmacol. 2010 Sep 15;131(2):502-4.

    Analgesic and anti-inflammatory activities of 11-O-galloylbergenin.[Pubmed: 20603209 ]
    Current study was designed to explore the analgesic and anti-inflammatory effects of a constituent isolated from Mallotus philippinensis, in order to validate its folk use. MATERIALS AND METHODS:11-O-Galloylbergenin was isolated from ethanolic extract of Mallotus philippinensis. Analgesic and anti-inflammatory activities of the test compound were assessed using formalin test and carrageenan-induced paw edema models.RESULTS:11-O-Galloylbergenin showed significant analgesic activity at doses of 20 and 40 mg/kg against formalin test in rats. Similarly, 11-O-Galloylbergenin exhibited significant anti-inflammatory activity in carrageenan-induced paw edema model at doses of 10, 20 and 30 mg/kg.
    Citation [2]

    Trop Biomed. 2014 Mar;31(1):143-8.

    Comparative antioxidant and antiplasmodial activities of 11-O-galloylbergenin and bergenin isolated from Bergenia ligulata.[Pubmed: 24862054]
    In the present study, the antioxidant and antiplasmodial activities of bergenin was compared with its natural derivative 11-O-Galloylbergenin for the first time. Both compounds were isolated from Bergenia ligulata. 11-O-Galloylbergenin was found to be very active in in-vitro antioxidant assay as compared to bergenin, which was found to be almost inactive. The EC50 values of 11-O-Galloylbergenin were 7.45±0.2 μg/mL and 5.39±0.28 μg/mL in DPPH antioxidant assay and reducing power assay respectively, while IC50 value for antiplasmodial assay of both compounds were less than 2.5 μM. Interestingly, in the total antioxidant phosphomolybdate assay, 11-O-Galloylbergenin was found more potent (CAHT: 940.04±115.30) as compared to α-tocopherol (CAHT: 552.4±27.91).
    Citation [3]

    Nat Prod Res. 2015;29(24):2291-4.

    Structure activity relationship of bergenin, p-hydroxybenzoyl bergenin, 11-O-galloylbergenin as potent antioxidant and urease inhibitor isolated from Bergenia ligulata.[Pubmed: 25674661]
    Ethanol extract of the aerial parts of Bergenia ligulata was subjected to solvent-solvent separation followed by various chromatographic techniques that lead to isolation of bergenine (1), p-hydroxybenzoyl bergenin (2), 11-O-Galloylbergenin (3) and methyl gallate (4) as major constituents. Ethyl acetate fraction showed a dose-dependent urease inhibitory pattern with IC50 value of 54μg/mL. Structures of compounds 1 and 3 were established by XRD and 2, 4 by NMR. All these compounds were subjected to DPPH scavenging activity, reducing power assay and urease inhibitory activity. The EC50 7.45 ± 0.2 μg/mL and 5.39 ± 0.28 μg/mL values in terms of antioxidant and reducing power, respectively, were less for 3. Compounds 1-3 showed moderate to significant urease inhibitory potential with IC50 57.1 ± 0.7, IC50 48.4 ± 0.3 and 38.6 ± 1.5. Antioxidant activities and urease inhibitory potential were investigated and compound 3 was found to be the most active.