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    2-(2'-Hydroxytetracosanoylamino)-octadecane-1,3,4-triol
    Information
    CAS No. 154801-30-6 Price
    Catalog No.CFN99649Purity>=98%
    Molecular Weight684.1 Type of CompoundCerebrosides
    FormulaC42H85NO5Physical DescriptionPowder
    Download Manual    COA    MSDSSimilar structuralComparison (Web)
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    Biological Activity
    Description: (2S,3S,4R,2′R)-2-(2′-hydroxytetracosanoylamino)octadecane-1,3,4-triol shows selectively inhibitory activity against phospholipase A 2 (PLA 2) secreted from Crotalus adamenteus venom at concentration of 100 ug/mL.
    Targets: Phospholipase (e.g. PLA)
    In vitro:
    Chinese Journal of Organic Chemistry, 2003, 23(8): 853-7.
    Chemical constituents of the fungus Leccinum extremiorientale.[Reference: WebLink]

    METHODS AND RESULTS:
    Thirteen chemical constituents were isolated from the fruiting bodies of basidiomyctes Leccinum extremiorientale, and their structures were elucidated by spectral and physical-chemical data as: ergosta-7,22-dien3β,5α ,6β-triol (1), ergosterol peroxide (2), ergosterol (3), ergosta-4,6,8(14),22-tetraen-3-one (4), ergosta-5,7-dien-3β-ol (5), palmitic acid (6), (2S,3S,4R,2′R )-2-(2'-Hydroxytetracosanoylamino)-octadecane-1,3,4-triol (7), cerebroside B (8), cerebroside D (9), uracil (10), inosine (11), adeosine (12) and D-allitol (13). The NMR data of compounds 8 and 9 were completely assigned by 2D-NMR techniques, including 1H- 1H COSY, HMBC and HMQC.
    CONCLUSIONS:
    Compounds 2, 7 and 8 at concentration of 100 μg/mL showed selectively inhibitory activity against phospholipase A 2 (PLA2) secreted from Crotalus adamenteus venom, but inactive against PLA2 of bee venom (Apis mellifcra). In addition, the methanol-chloroform soluble extract of this fungus also showed 67% antifeedant rate against Leucaninia separata and caused 55% mortality against Plutella xylostella after three-day application.
    2-(2'-Hydroxytetracosanoylamino)-octadecane-1,3,4-triol Description
    Source: The fruits of Evodia rutaecarpa
    Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.

    PMID: 29328914

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.

    PMID: 29149595

    Scientific Reports 2017 Dec 11;7(1):17332.
    doi: 10.1038/s41598-017-17427-6.

    PMID: 29230013

    Molecules. 2017 Oct 27;22(11). pii: E1829.
    doi: 10.3390/molecules22111829.

    PMID: 29077044

    J Cell Biochem. 2018 Feb;119(2):2231-2239.
    doi: 10.1002/jcb.26385.

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    PMID: 29496173
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.4618 mL 7.3089 mL 14.6177 mL 29.2355 mL 36.5444 mL
    5 mM 0.2924 mL 1.4618 mL 2.9235 mL 5.8471 mL 7.3089 mL
    10 mM 0.1462 mL 0.7309 mL 1.4618 mL 2.9235 mL 3.6544 mL
    50 mM 0.0292 mL 0.1462 mL 0.2924 mL 0.5847 mL 0.7309 mL
    100 mM 0.0146 mL 0.0731 mL 0.1462 mL 0.2924 mL 0.3654 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Structure Identification:
    Lipids. 2001 Feb;36(2):175-80.
    A new ceramide from the basidiomycete Russula cyanoxantha.[Pubmed: 11269698]

    METHODS AND RESULTS:
    A new phytosphingosine-type ceramide (1) was isolated along with nine other compounds-5alpha,8alpha-epidioxy(22E,24R)-ergosta-6,22-dien-3beta-ol, 5alpha,8alpha-epidioxy-(24S)-ergosta-6-en-3beta-ol, (24S)-ergosta-7-ene-3beta,5alpha,6beta-triol, (22E,24R)-ergosta-7,22-dien-3beta,5alpha,6beta-triol, inosine, adenine, L-pyroglutamic acid, fumaric acid, and D-allitol from the ethanol and chloroform/methanol extract of the fruiting bodies of the basidiomycete Russula cyanoxanotha (Schaeff.) Fr.
    CONCLUSIONS:
    The structure of (1) was established as (2S,3S,4R,2'R)-2-(2'-Hydroxytetracosanoylamino)-octadecane-1,3,4-triol by means of spectroscopic and chemical methods.