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3-Hydroxy-3-acetonyloxindole
3-Hydroxy-3-acetonyloxindole
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name 3-Hydroxy-3-acetonyloxindole
Price:
CAS No.: 33417-17-3
Catalog No.: CFN96171
Molecular Formula: C11H11NO3
Molecular Weight: 205.2 g/mol
Purity: >=98%
Type of Compound: Alkaloids
Physical Desc.: Powder
Source: The herbs of Marsdenia tinctoria
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF
Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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Product Use Citation
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Standard reference
In vivo:
Acta Physiol Pharmacol Latinoam. 1986;36(4):391-5.
Biological studies on indole derivatives. I. Synthesis and pharmacological studies of 2-oxo-3-indolyl derivatives.[Pubmed: 3604703]

METHODS AND RESULTS:
Two compounds, 3-Hydroxy-3-acetonyloxindole (I) and compound 3-acetonylidene-oxindole (II) were synthesized by a convenient method, and their pharmacological/toxicological effects were studied in rabbit.
CONCLUSIONS:
These compounds produced transitory effects on serum enzymes. The cholesterol mobilizing effect is more prominent with compound (I).
3-Hydroxy-3-acetonyloxindole Description
Source: The herbs of Marsdenia tinctoria
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
More...

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

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Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 4.8733 mL 24.3665 mL 48.7329 mL 97.4659 mL 121.8324 mL
5 mM 0.9747 mL 4.8733 mL 9.7466 mL 19.4932 mL 24.3665 mL
10 mM 0.4873 mL 2.4366 mL 4.8733 mL 9.7466 mL 12.1832 mL
50 mM 0.0975 mL 0.4873 mL 0.9747 mL 1.9493 mL 2.4366 mL
100 mM 0.0487 mL 0.2437 mL 0.4873 mL 0.9747 mL 1.2183 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
J Pharm Sci. 1980 Oct;69(10):1235-7.
Synthesis of potential anticonvulsants: condensation of isatins with acetone and related ketones.[Pubmed: 6158569]

METHODS AND RESULTS:
Substituted isatins were condensed with acetone and other ketones to give analogs of 3-Hydroxy-3-acetonyloxindole. Some of these alcohols were dehydrated. Several compounds with anticonvulsant activity were obtained.
CFN00443Gramodendrine83905-67-3337.40C21H27N3O
CFN900015-[(2R)-2-Aminopropyl]-2,3-dihydro-1-[3-(phenylmethoxy)propyl]-1H-indole-7-carbonitrile459868-73-6349.47C22H27N3O
CFN900235-[(2R)-2-Aminopropyl]-1-[3-(benzoyloxy)propyl]-2,3-dihydro-1H-indole-7-carbonitrile (2R,3R)-2,3-dihydroxybutanedioate239463-85-5513.55C26H31N3O8
CFN961713-Hydroxy-3-acetonyloxindole33417-17-3205.2C11H11NO3
CFN93321Tamoxifen10540-29-1371.51C26H29NO
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