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    4-Hydroxybenzyl alcohol
    CAS No. 623-05-2 Price $30 / 20mg
    Catalog No.CFN97071Purity>=98%
    Molecular Weight124.1 Type of CompoundPhenols
    FormulaC7H8O2Physical DescriptionPowder
    Download Manual    COA    MSDSSimilar structuralComparison (Web)
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    Biological Activity
    Description: 4-Hydroxybenzyl alcohol possesses anti-angiogenic, anti-inflammatory and anti- nociceptive activity possibly via its down-regulating activity on NO production, which may be partly responsible for the pharmacological efficacy of several folkloric medicines. It exhibits beneficial effects in cerebral ischemic injury, has neuroprotective effect through upregulation of Nrf2, Prdx6, and PDI expression via the PI3K/Akt pathway.
    Targets: Nrf2 | PI3K | Akt | JNK | NF-kB | NO | NOS | Bcl-2/Bax | Caspase | ROS
    In vitro:
    Life Sci. 2013 Jul 19;93(1):44-50.
    4-hydroxybenzyl alcohol: a novel inhibitor of tumor angiogenesis and growth.[Pubmed: 23743167]
    The herbal compound 4-Hydroxybenzyl alcohol (HBA) is a pleiotropic agent, which has been shown to effectively inhibit the development of new blood vessels by targeting multiple mechanisms of the angiogenic process. Because angiogenesis is a major prerequisite for tumor growth, the aim of this study was to analyze for the first time, whether 4-Hydroxybenzyl alcohol may be used for anti-cancer therapy.
    CT26.WT colon carcinoma cells were exposed to different 4-Hydroxybenzyl alcohol doses to study their viability, migration, invasiveness and protein expression compared to vehicle-treated controls. Moreover, CT26.WT cell spheroids were transplanted into the dorsal skinfold chamber of 4-Hydroxybenzyl alcohol-treated and vehicle-treated BALB/c mice for the analysis of tumor vascularization and growth by means of repetitive intravital fluorescence microscopy, histology and immunohistochemistry. As shown by water-soluble tetrazolium (WST)-1 and lactate dehydrogenase (LDH) assays, 4-Hydroxybenzyl alcohol treatment dose-dependently reduced the viability and integrity of the tumor cells. Moreover, phalloidin staining of 4-Hydroxybenzyl alcohol-treated cells revealed a disorganized cytoskeleton, which was associated with a decreased cellular migratory and invasive activity. Finally, 4-Hydroxybenzyl alcohol treatment inhibited the vascularization and growth of newly developing CT26.WT tumors in the mouse dorsal skinfold chamber model without affecting the normal behavior of the animals.
    These novel findings indicate that 4-Hydroxybenzyl alcohol represents a promising candidate for the establishment of anti-angiogenic treatment strategies in cancer therapy.
    J Ethnopharmacol. 2012 Jan 31;139(2):549-57.
    Modulation of LPS-stimulated neuroinflammation in BV-2 microglia by Gastrodia elata: 4-hydroxybenzyl alcohol is the bioactive candidate.[Pubmed: 22155394]
    4-Hydroxybenzyl alcohol (HBA) is a phenolic plant compound, which has been shown to influence many cellular mechanisms. In the present study, we analysed in vitro and in vivo the anti-angiogenic actions of this pleiotropic agent.
    Migration and protein expression of 4-Hydroxybenzyl alcohol- and vehicle-treated endothelial-like eEND2 cells was assessed by cell migration assay and Western blot analyses. 4-Hydroxybenzyl alcohol action on vascular sprouting was analysed in an aortic ring assay. In vivo anti-angiogenic actions of 4-Hydroxybenzyl alcohol were studied in the dorsal skinfold chamber model of endometriosis in mice. Western blot analyses demonstrated that 4-Hydroxybenzyl alcohol inhibited proliferation of eEND2 cells, as indicated by down-regulation of proliferating cell nuclear antigen expression, and reduced expression of vascular endothelial growth factor and matrix metalloproteinase 9. 4-Hydroxybenzyl alcohol suppressed the migration of eEND2 cells, accompanied by inhibition of actin filament reorganization, revealed by fluorescence staining of the cytoskeleton. In addition, 4-Hydroxybenzyl alcohol reduced vascular sprouting in the aortic ring assay. Finally, we found, in the dorsal skinfold chamber model in vivo using intravital fluorescence microscopy, that 4-Hydroxybenzyl alcohol inhibited the vascularization of developing endometriotic lesions, as indicated by a decreased functional capillary density of lesions in 4-Hydroxybenzyl alcohol-treated mice and a reduced lesion size, compared with control animals.
    4-Hydroxybenzyl alcohol targets several angiogenic mechanisms and therefore represents a promising anti-angiogenic agent for the treatment of angiogenic diseases, such as endometriosis.
    In vivo:
    J Pharm Pharmacol. 2007 Sep;59(9):1235-40.
    Anti-angiogenic, anti-inflammatory and anti-nociceptive activity of 4-hydroxybenzyl alcohol.[Pubmed: 17883894 ]

    4-Hydroxybenzyl alcohol (HBA), one of the well-known phenolic compounds in diverse plants, displayed a significant inhibition in the chick chorioallantoic membrane (CAM) angiogenesis assay. HBA was shown to contain an anti-inflammatory activity in carrageenan-induced air pouch model in rats and acetic acid-induced permeability model in mice. Anti-nociceptive activity of HBA was also assessed using the acetic acid-induced writhing test in mice. HBA was able to suppress production of nitric oxide (NO) and expression of inducible nitric oxide synthase (iNOS) in lipopolysaccharide (LPS)-activated RAW264.7 macrophages. In the macrophages, the level of reactive oxygen species (ROS) was diminished by HBA.
    Taken together, HBA possesses anti-angiogenic, anti-inflammatory and anti-nociceptive activity possibly via its down-regulating activity on NO production, which may be partly responsible for the pharmacological efficacy of several folkloric medicines.
    4-Hydroxybenzyl alcohol Description
    Source: The herbs of Cistanche deserticola Ma.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 8.058 mL 40.2901 mL 80.5802 mL 161.1604 mL 201.4504 mL
    5 mM 1.6116 mL 8.058 mL 16.116 mL 32.2321 mL 40.2901 mL
    10 mM 0.8058 mL 4.029 mL 8.058 mL 16.116 mL 20.145 mL
    50 mM 0.1612 mL 0.8058 mL 1.6116 mL 3.2232 mL 4.029 mL
    100 mM 0.0806 mL 0.4029 mL 0.8058 mL 1.6116 mL 2.0145 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Kinase Assay:
    Neurochem Res. 2013 Jul;38(7):1501-16.
    4-Hydroxybenzyl alcohol confers neuroprotection through up-regulation of antioxidant protein expression.[Pubmed: 23624876]
    An herb-derived phenolic compound, 4-Hydroxybenzyl alcohol (4-HBA), exhibits beneficial effects in cerebral ischemic injury. However, the molecular mechanisms underlying this observation remain unclear.
    Here we used an in vitro ischemic model of oxygen-glucose deprivation followed by reperfusion (OGD/R) and an in vivo ischemic model of middle cerebral artery occlusion to investigate the relevant neuroprotective mechanisms. We demonstrated that 4-HBA reduced the neuronal injury, LDH release, and up-regulation of 8-hydroxydeoxyguanosine (8-OHdG) induced by OGD/R. Furthermore, 4-HBA reduced the cerebral infarct size and improved the behavioral parameters after cerebral ischemia. These neuroprotective effects may be conferred by the 4-HBA mediated upregulation of the transcription factor nuclear factor E2-related factor 2 (Nrf2), peroxiredoxin 6 (Prdx6) and protein disulfide isomerase (PDI) by the use of 4-HBA. Interestingly, LY294002, a phosphatidylinositol 3-kinase (PI3K) inhibitor, blocked the increase in phosphorylation of Akt and abolished the neuroprotection associated with 4-HBA.
    Our results suggested that 4-HBA protects neurons against cerebral ischemic injury, and this neuroprotection may occur through upregulation of Nrf2, Prdx6, and PDI expression via the PI3K/Akt pathway.
    Animal Research:
    Brain Res. 2010 Jan 13;1308:167-75.
    Neuroprotective effect of 4-hydroxybenzyl alcohol against transient focal cerebral ischemia via anti-apoptosis in rats.[Pubmed: 19857470]
    4-Hydroxybenzyl alcohol (4-HBA), one of the major active phenolic constituents of Gastrodia elata Blume, a very important traditional Chinese medicinal herb, has been shown to be an effective agent against the central and peripheral nervous disorders.
    In this study, we attempted to explore the possible mechanisms underlying the neuroprotection against transient focal cerebral ischemia by 4-HBA.4-HBA (25, 50 mg/kg) was given 30 min before focal ischemia in rats caused by middle cerebral artery occlusion (1 h of occlusion, 24 h of reperfusion). Under the treatment of 50 mg/kg 4-HBA, total (100.76+/-2.90 mm(3)), cortical (64.91+/-1.46 mm(3)), and sub-cortical (38.77+/-2.78 mm(3)) infarct volumes were significantly decreased in comparison to ischemia-reperfusion values. Neurological evaluation and Nissl-staining of the 4-HBA group were improved significantly compared to the untreated ischemia group. TUNEL-positive cells were reduced significantly in 4-HBA treated group. Results of immunofluorescence staining analysis and Western immunoblot indicated that 4-HBA increased the expression of Bcl-2 and inhibited the activation of caspase-3 ultimately inhibiting apoptosis.
    These results suggested that 4-HBA ameliorated ischemic injury induced by transient focal cerebral ischemia in rats, and this neuroprotective effect may be partly related to attenuate apoptosis pathway.