4-Hydroxyisophthalic acid | CAS:636-46-4

4-Hydroxyisophthalic acid

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Description:

4-Hydroxyisophthalic acid has analgesic and antipyretic activities.It could be a promising natural antioxidant and a neuroprotective molecule targeting oxidative stress-mediated mitochondrial dysfunction with therapeutic potential for neurodegenerative disorders.

In vitro:

Neurotoxicology, 2018,46:160-169.

Neuroprotective action of 4-Hydroxyisophthalic acid against paraquat-induced motor impairment involves amelioration of mitochondrial damage and neurodegeneration in Drosophila.[Reference: WebLink]

Neurodegenerative disorders including Parkinson’s disease (PD) are believed to be caused by oxidative stress and mitochondrial dysfunction. Exposure to environmental agents such as pesticides has been implicated in the etiology of sporadic PD. Paraquat (PQ), a widely used herbicide, induces PD symptoms in laboratory animals including Drosophila. PQ acts as a free radical generator and induces oxidative damage, which is implicated in neuronal cell death. Drosophila model of PQ-induced PD offers a convenient tool for mechanistic studies and, to assess the neuroprotective potential of natural antioxidants.
METHODS AND RESULTS:
We have investigated the neuroprotective potential of 4-Hydroxyisophthalic acid (DHA-I), a novel bioactive molecule from the roots of Decalepis hamiltonii, against PQ-induced locomotor impairment and neurodegeneration in Drosophila melanogaster. Our study shows that PQ treatment results in movement disorder associated with oxidative stress-mediated mitochondrial damage and neurodegeneration in the brain as evident by ultrastructural observations. Treatment with DHA-I markedly attenuated locomotor deficits, oxidative stress, mitochondrial damage, and neurodegenerative changes induced by PQ in Drosophila.
CONCLUSIONS:
Our results show that DHA-I could be a promising natural antioxidant and a neuroprotective molecule targeting oxidative stress-mediated mitochondrial dysfunction with therapeutic potential for neurodegenerative disorders.

4-Hydroxyisophthalic acid Description

Source:	The roots of Decalepis hamiltonii
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Structure Identification:

Nature, 1955, 175(4448):206.

Analgesic and Antipyretic Activities of 4-Hydroxyisophthalic Acid.[Reference: WebLink]

Analgesic and Antipyretic Activities of 4-Hydroxyisophthalic acid
METHODS AND RESULTS:
4-Hydroxyisophthalic acid is a by-product of the manufacture of salicylic acid by the Kolbe-Schmitt reaction and has been found to be a major constituent of the `brown dust' residues from the sublimation process for the purification of salicylic acid1. Analysis of a typical sample of `brown dust' showed it to contain 10 per cent of salicylic, 82 per cent of 4-hydroxyisophthalic and 3 per cent of 2-hydroxyisophthalic acids, together with some inorganic material. From this source there is thus potentially available a considerable quantity of 4-Hydroxyisophthalic acid, the chemistry of which is being investigated as part of a research programme on the Kolbe-Schmitt reaction at the Chemical Research Laboratory2. From a consideration of its structural similarity to salicylic acid, it was suggested at the Chemical Research Laboratory that 4-Hydroxyisophthalic acid might also possess similar pharmacological properties.
CONCLUSIONS:
Accordingly, in February 1954, a pharmacological investigation was initiated at Ware and, since the findings were favourable, biochemical studies were also undertaken.

Product Name	4-Hydroxyisophthalic acid
Price:	$30 / 20mg
CAS No.:	636-46-4
Catalog No.:	CFN70178
Molecular Formula:	C₈H₆O₅
Molecular Weight:	182.1 g/mol
Purity:	>=98%
Type of Compound:	Phenols
Physical Desc.:	Powder
Source:	The roots of Decalepis hamiltonii
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Phenols Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	5.4915 mL	27.4574 mL	54.9149 mL	109.8298 mL	137.2872 mL
5 mM	1.0983 mL	5.4915 mL	10.983 mL	21.966 mL	27.4574 mL
10 mM	0.5491 mL	2.7457 mL	5.4915 mL	10.983 mL	13.7287 mL
50 mM	0.1098 mL	0.5491 mL	1.0983 mL	2.1966 mL	2.7457 mL
100 mM	0.0549 mL	0.2746 mL	0.5491 mL	1.0983 mL	1.3729 mL

CFN99302	Coronarin D	119188-37-3	318.5	C₂₀H₃₀O₃
CFN96641	Taxagifine	81489-69-2	696.74	C₃₇H₄₄O₁₃
CFN99871	Byzantionoside B	189109-45-3	372.5	C₁₉H₃₂O₇
CFN60143	T0070907	313516-66-4	277.66	C₁₂H₈ClN₃O₃