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    5,5'-Dimethoxysecoisolariciresinol
    5,5'-Dimethoxysecoisolariciresinol
    Information
    CAS No. 1002106-91-3 Price
    Catalog No.CFN92963Purity>=98%
    Molecular Weight422.47Type of CompoundLignans
    FormulaC22H30O8Physical DescriptionPowder
    Download     COA    MSDSSimilar structuralComparison (Web)
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    5,5'-Dimethoxysecoisolariciresinol Description
    Source: The Heartwood of Podocarpus spicata
    Biological Activity or Inhibitors:
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.

    PMID: 29328914

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.

    PMID: 29149595

    Scientific Reports 2017 Dec 11;7(1):17332.
    doi: 10.1038/s41598-017-17427-6.

    PMID: 29230013

    Molecules. 2017 Oct 27;22(11). pii: E1829.
    doi: 10.3390/molecules22111829.

    PMID: 29077044

    J Cell Biochem. 2018 Feb;119(2):2231-2239.
    doi: 10.1002/jcb.26385.

    PMID: 28857247

    Phytomedicine. 2018 Feb 1;40:37-47.
    doi:10.1016/j.phymed.2017.12.030

    PMID: 29496173
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.367 mL 11.8352 mL 23.6703 mL 47.3406 mL 59.1758 mL
    5 mM 0.4734 mL 2.367 mL 4.7341 mL 9.4681 mL 11.8352 mL
    10 mM 0.2367 mL 1.1835 mL 2.367 mL 4.7341 mL 5.9176 mL
    50 mM 0.0473 mL 0.2367 mL 0.4734 mL 0.9468 mL 1.1835 mL
    100 mM 0.0237 mL 0.1184 mL 0.2367 mL 0.4734 mL 0.5918 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    5,5'-Dimethoxysecoisolariciresinol References Information
    Citation [1]

    Planta Med. 2010 Feb;76(3):294-7.

    New secoisolariciresinol derivatives from Lindera obtusiloba stems and their neuroprotective activities.[Pubmed: 19708005 ]
    A methanolic extract of Lindera obtusiloba (Lauraceae) stems significantly attenuated glutamate-induced oxidative stress in HT22 hippocampal cells. Two new secoisolariciresinol derivatives, characterized as 9,9'- O-di-(E)-feruloyl-meso-5,5'-Dimethoxysecoisolariciresinol (1) and 9,9'-O-di-(E)-sinapinoyl-meso-5,5'-Dimethoxysecoisolariciresinol (2), were isolated, along with the known compound 9,9'-O-di-(E)-feruloyl-meso-secoisolariciresinol (3), from the methanolic extract of L. obtusiloba stems. Compounds 1, 2, and 3 showed neuroprotective effects on glutamate-induced toxicity in HT22 cells.
    Citation [2]

    Zhong Yao Cai. 2015 May;38(5):972-4.

    Chemical Constitutes from Root of Artocarpus styracifolius.[Pubmed: 26767289]
    To study the chemical constituents from root of Artocarpus styracifolius. METHODS: Tne constituents were isolated from the root of Artocarpus styracifolius by column chromatography over silica gel, RP-18 silica gel, MCI GEL CHP-20P, macroporous resin HP-20, Sephadex LH-20, Toyopearl HW-40C and by preparative HPLC. Their structures were elucidated by analysis of physical and chemical properties and spectral data. RESULTS: Nine compounds were isolated and their structures were identified as p-hydroxy benzoic acid (1), syringic acid (2), 2,4-dihydroxy benzaldehyde (3), (+)-lyoniresinol (4), 5,5'-Dimethoxysecoisolariciresinol (5), (+)- syringaresinol (6), scopoletin (7), xylarolide (8) and trans-oxyresveratrol (9). CONCLUSION: Compounds 2, 5, 6 and 8 are isolated from Moraceae for the first time. Compounds 1, 4 and 7 are firstly characterized in the genus Artocarpus, compounds 3 and 9 are characterized in Artocarpus styracifolius for the first time.