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More articles cited ChemFaces products.
Phytochem Anal.2013, 24(5):493-503Mol Med Rep.2015, 12(5):7789-95Phytomedicine.2015, 22(14):1262-8Chemistr of plant2016, 2016021195Phytomedicine.2016, 23(4):331-9Mol Pharm.2017, 14(9):3164-3177Phytochemistry.2017, 141:162-170Molecules.2017, 22(3)
Cytotechnology.2017, 69(5):765-773BMC Complement Altern Med....2018...Front Plant Sci.2018, 9:1424Wageningen University & Research...2018...Analytical methods2019, 11(6)Chemistry of Plant Materials....2019...International J of Green Pharmacy...2019...Molecules.2019, 24(7):E1290
The Malaysian journal of patholog...2019...Aquaculture2019, 510:392-399Phytomedicine.2019, 67:153159Biomolecules.2020, 10(2):E184Pharmacological Reports2020, 1-9J Sep Sci.2020, 201901140J Mol Recognit.2020, 33(2):e2819
Our products had been exported to the following research institutions and universities, And still growing.
Heidelberg University (Germany)The Institute of Cancer Research (United Kingdom)Complutense University of Madrid (Spain)Korea Food Research Institute(K... (Korea)
Warszawski Uniwersytet Medyczny (Poland)Instytut Nawozów Sztucznych w ... (Poland)Uniwersytet Gdański (Poland)Medical University of South Car... (USA)
Gyeongsang National University (Korea)Universidad Industrial de Santa... (Colombia)University of Perugia (Italy)
Related Screening Libraries
|| 6',7'-Dihydroxybergamottin is a potent inhibitor of CYP3A activity, and may be primarily responsible for the effects of grapefruit juice on cytochrome P450 activity in humans. |
||P450 (e.g. CYP17)|
6',7'-Dihydroxybergamottin acetonide Description
||The peels of Citrus maxima
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: firstname.lastname@example.org
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Recent ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
|Drug Metab Dispos. 1996 Dec;24(12):1287-90. |
|Identification of 6',7'-dihydroxybergamottin, a cytochrome P450 inhibitor, in grapefruit juice.[Pubmed: 8971132]|
|Grapefruit juice inhibits the metabolism of substrates for enzymes of the CYP3A subfamily. However, the identity of the inhibitor has not been established.
METHODS AND RESULTS:
Grapefruit juice was extracted into methylene chloride and chromatographed by HPLC, and the effect of the HPLC eluent on CYP3A activity was assessed by measuring 6beta-hydroxytestosterone formation in rat liver microsomes. Significant inhibition was associated with a fraction of HPLC eluent containing a single peak, with a retention time of 16 min. The substance producing this peak was isolated using TLC and identified, using NMR and MS, as 6',7'-dihydroxybergamottin (C21H2406; molecular weight, 372), a furanocoumarin (psoralen) compound. The concentration of 6',7'-dihydroxybergamottin required to inhibit 6beta-hydroxytestosterone formation by 50% was 25 microM. Grapefruit juice reduced CYP3A activity to a significantly greater extent (p < 0.05) than did orange juice, which contained no measurable 6',7'-dihydroxybergamottin (28.6% vs. 62.2% of control activity). The addition of 6',7'-dihydroxybergamottin (30 microM) to orange juice decreased CYP3A activity to values comparable to those observed with grapefruit juice.
6',7'-Dihydroxybergamottin is a potent inhibitor of CYP3A activity, accounts for the difference in inhibition between grapefruit juice and orange juice in vitro, and may be primarily responsible for the effects of grapefruit juice on cytochrome P450 activity in humans.