| Structure Identification: |
| Chinese Traditional & Herbal Drugs, 2001 (12) :1063-1065. | | Studies on chemical constituents of Callicarpa pedunculata[Reference: WebLink] | To study the chemical constituents of whole plant of Callicarpa pedunculata R Brown.
METHODS AND RESULTS:
Various chromatographic techniques were employed for isolation and purification of its constituents; and their structures were identified by spectral analysis (IR, MS, 1HNMR, 13 CNMR) and chemical evidences.Ten compounds were obtained from the chloroform extract of the whole plant Among them four were diterpenoids which were identified as: 14 α-hydroxy-7, 15-isopimaradien-18-oic acid (Ⅰ), 16 α, 17-dihydroxy-3-oxo-phyllocladanetriol (Ⅱ), 8, 11, 13, 15-abietetraen-18-oic acid (Ⅲ), and 6alpha-Hydroxynidorellol (Ⅳ); 2 flavonoids: 5-hydroxy-3, 4′, 7-trimethoxy-flavone (Ⅴ), and 3, 5-dimethyl kaempherol (Ⅵ); and the others were ursolic acid (Ⅶ), myoinositol (Ⅷ), β-sitosterol (Ⅸ), and β-amyrin (Ⅹ).
CONCLUSIONS:
Compounds Ⅰ, Ⅱ, Ⅲ, Ⅳ were found in this plant for the first time and it was of interest to note that they were of different diterpenoid skeletons The content of ursolic acid attained to a high level up to 1%, which may be exploited as a natural resource for medical purposes. |
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