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8'-Epicleomiscosin A
8'-Epicleomiscosin A
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name 8'-Epicleomiscosin A
Price:
CAS No.: N/A
Catalog No.: CFN90101
Molecular Formula: C20H18O8
Molecular Weight: 386.36 g/mol
Purity: >=98%
Type of Compound: Coumarins
Physical Desc.: Powder
Source: The herbs of Buxus sinica
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF
Similar structural: Comparison (Web)  (SDF)
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: 8'-Epicleomiscosin A shows strong inhibition (IC50=1.33 microM) against the enzyme tyrosinase, as compared to the standard tyrosinase inhibitors kojic acid (IC50=16.67 microM) and L-mimosine (IC50=3.68 microM), indicating its potential used for the treatment of hyperpigmentation associated with the high production of melanocytes.
8'-Epicleomiscosin A Description
Source: The herbs of Buxus sinica
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
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Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.5883 mL 12.9413 mL 25.8826 mL 51.7652 mL 64.7065 mL
5 mM 0.5177 mL 2.5883 mL 5.1765 mL 10.353 mL 12.9413 mL
10 mM 0.2588 mL 1.2941 mL 2.5883 mL 5.1765 mL 6.4706 mL
50 mM 0.0518 mL 0.2588 mL 0.5177 mL 1.0353 mL 1.2941 mL
100 mM 0.0259 mL 0.1294 mL 0.2588 mL 0.5177 mL 0.6471 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Kinase Assay:
Chemical & Pharmaceutical Bulletin [2004, 52(12):1458-1461]
Tyrosinase inhibitors from Rhododendron collettianum and their structure-activity relationship (SAR) studies.[Reference: WebLink]

METHODS AND RESULTS:
A new coumarinolignoid 8'-Epicleomiscosin A (1) together with the new glycoside 8-O-beta-D-glucopyranosyl-6-hydroxy-2-methyl-4H-1-benzopyrane-4-one (2) have been isolated from the aerial parts of Rhododendron collettianum and their structures determined on the basis of spectroscopic evidences. Tyrosinase inhibition study of these compounds and their structure-activity relationship (SAR) were also investigated.
CONCLUSIONS:
The compounds exhibited potent to mild inhibition activity against the enzyme. Especially, 8'-Epicleomiscosin A showed strong inhibition (IC50=1.33 microM) against the enzyme tyrosinase, as compared to the standard tyrosinase inhibitors kojic acid (IC50=16.67 microM) and L-mimosine (IC50=3.68 microM), indicating its potential used for the treatment of hyperpigmentation associated with the high production of melanocytes.
CFN94004Cleomiscosin B76985-93-8386.36C20H18O8
CFN901018'-Epicleomiscosin AN/A386.36C20H18O8
CFN97252Cleomiscosin A76948-72-6386.4 C20H18O8
CFN969976-Demethoxycleomiscosin A121587-20-0356.33C19H16O7
CFN969966-Demethoxy-9'-deoxycleomiscosin A121587-18-6340.33C19H16O6
CFN983885'-Demethylaquillochin305364-91-4402.4 C20H18O9
CFN97400Cleomiscosin C84575-10-0416.4 C21H20O9
CFN95377Yinxiancaoside C1159908-74-3578.5C27H30O14
CFN99333Moluccanin121700-26-3386.4 C20H18O8
CFN99334Moluccanin diacetate121700-27-4470.4 C24H22O10
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