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    CAS No. 509-20-6 Price $448 / 20mg
    Catalog No.CFN90248Purity>=98%
    Molecular Weight499.60Type of CompoundAlkaloids
    FormulaC25H41NO9Physical DescriptionPowder
    Download Manual    COA    MSDS    SDFSimilar structuralComparison (Web)
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    Aconine Description
    Source: The roots of Aconitum kusnezoffii Reichb.
    Biological Activity or Inhibitors: 1. Aconine is the febrifuge.
    2. Aconine possesses gastric anaesthetic props.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.

    PMID: 29328914

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.

    PMID: 29149595

    Scientific Reports 2017 Dec 11;7(1):17332.
    doi: 10.1038/s41598-017-17427-6.

    PMID: 29230013

    Molecules. 2017 Oct 27;22(11). pii: E1829.
    doi: 10.3390/molecules22111829.

    PMID: 29077044

    J Cell Biochem. 2018 Feb;119(2):2231-2239.
    doi: 10.1002/jcb.26385.

    PMID: 28857247

    Phytomedicine. 2018 Feb 1;40:37-47.

    PMID: 29496173
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.0016 mL 10.008 mL 20.016 mL 40.032 mL 50.04 mL
    5 mM 0.4003 mL 2.0016 mL 4.0032 mL 8.0064 mL 10.008 mL
    10 mM 0.2002 mL 1.0008 mL 2.0016 mL 4.0032 mL 5.004 mL
    50 mM 0.04 mL 0.2002 mL 0.4003 mL 0.8006 mL 1.0008 mL
    100 mM 0.02 mL 0.1001 mL 0.2002 mL 0.4003 mL 0.5004 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Aconine References Information
    Citation [1]

    Nat Prod Commun. 2014 Jun;9(6):785-6.

    Ring A conformation of aconine and pseudaconine in CDCl3.[Pubmed: 25115078]
    On the basis of intensive interpretation of the 1H NMR spectroscopic data, the ring A conformation of Aconine (1) was speculated as twist boat in CDCl3, and as chair or twist boat in acetone-d6 and pyridine-d5. The ring A of pseudAconine (2) adopts the chair conformation in CDCl3, acetone-d6, and pyridine-ds. Accordingly, the boat conformation of ring A in these two diterpenoid alkaloids in CDCl3 reported in the literature [1] should be revised. The difference in 13C NMR data for the same compound (1 or 2) in two different solvents (CDCl3, pyridine-d5) can be attributed to solvent effects.
    Citation [2]

    J Pharm Sci. 1977 Sep;66(9):1331-2.

    Selective estimation of aconitine in presence of aconine and benzoylaconine.[Pubmed: 903876]
    A selective and simple colorimetric method is presented for the estimation of aconitine in drugs in the presence of Aconine and benzoylAconine. The method is based on the formation of an iron hydroxamate complex through the acetate ester group to which the biological activity is due. The color is measured at 530 nm (5--250 microgram/ml). Under the experimental conditions, neither the benzoyl group of benzoylAconine nor Aconine is involved in the process of hydroxylaminolysis.
    Citation [3]

    Zhongguo Zhong Yao Za Zhi. 2014 Dec;39(24):4798-803.

    [Effects of steaming and baking on content of alkaloids in Aconite Lateralis Radix (Fuzi)].[Pubmed: 25898581]
    To study the effect of steaming and baking process on contents of alkaloids in Aconite Lateralis Radix (Fuzi), 13 alkaloids were analyzed by UPLC-MS/MS equipped with ESI ion source in MRM mode. In steaming process, the contents of diester-diterpenoid alkaloids decreased rapidly, the contents of monoester-diterpenoid alkaloids firstly increased, reached the peak at 40 min, and then deceased gradually. The contents of Aconine alkaloids (mesAconine, Aconine and hypAconine) increased all the time during processing, while the contents of fuziline, songorine, karacoline, salsolionl were stable or slightly decreased. In baking process, dynamic variations of alkaloids were different from that in the steaming process. Diester-diterpenoid alkaloids were degraded slightly slower than in steaming process. Monoester-diterpenoid alkaloids, Aconine alkaloids and the total alkaloids had been destroyed at different degrees, their contents were significantly lower than the ones in steaming Fuzi at the same processing time. This experiment revealed the dynamic variations of alkaloids in the course of steaming and baking. Two processing methods which can both effectively remove the toxic ingredients and retain the active ingredients are simple and controllable, and are valuable for popularization and application.