|Source:||The herb of Artemisia annua L.|
|Biological Activity or Inhibitors:||1. Artemisinin has antimalarial activity.
2. Artemisinin inhibits tumor necrosis factor-α-induced vascular smooth muscle cell proliferation.
3. Artemisinin is active against different bacteria and certain fungal species.
|Solvent:||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.|
|Storage:||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: firstname.lastname@example.org
|After receiving:||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.|
|1 mg||5 mg||10 mg||20 mg||25 mg|
|1 mM||3.5423 mL||17.7117 mL||35.4233 mL||70.8466 mL||88.5583 mL|
|5 mM||0.7085 mL||3.5423 mL||7.0847 mL||14.1693 mL||17.7117 mL|
|10 mM||0.3542 mL||1.7712 mL||3.5423 mL||7.0847 mL||8.8558 mL|
|50 mM||0.0708 mL||0.3542 mL||0.7085 mL||1.4169 mL||1.7712 mL|
|100 mM||0.0354 mL||0.1771 mL||0.3542 mL||0.7085 mL||0.8856 mL|
Mutat Res Genet Toxicol Environ Mutagen. 2015 Jan 1;777:1-6.
|The antimalarial agent artesunate causes sperm DNA damage and hepatic antioxidant defense in mice.[Pubmed: 25726169]|
|Artesunate is an Artemisinin derivative effective against multidrug resistant malaria.
The present study suggests that artesunate has the potential to breach the testis-blood barrier and cause toxicity to male germ cells which may have implications in male reproductive toxicity.
Jpn J Infect Dis. 2015 Feb 13.
|Impact of Artemisinin-based Combination Therapy on falciparum malaria in urban Kolkata: a clinic based report.[Pubmed: 25720645]|
|In India combination of artesunate + sulphadoxine-pyrimethamine has been implemented for uncomplicated falciparum malaria since 2010. We observed the impact of this intervention in urban Kolkata by analyzing data of Malaria Clinic from 2001 to 2013. In Kolkata P. vivax is perennial whereas P. falciparum infection is seasonal. Before ACT implementation P. falciparum percentage was as high as 50% which steadily decreased during four successive years post intervention. No change was observed in case of vivax cases. ACT is probably an effective measure in reducing falciparum malaria cases. Any Artemisinin derivative combination should be explored in vivax malaria to reduce the overall malaria burden.|
Clin Exp Pharmacol Physiol. 2015 Feb 24.
|Artemisinin inhibits tumor necrosis factor-α-induced vascular smooth muscle cell proliferation in vitro and attenuates balloon injury-induced neointima formation in rats.[Pubmed: 25707499]|
|The aim of this study was to evaluate the effect of Artemisinin (ART) on the proliferation, cell cycle arrest as well as apoptosis induced by tumor necrosis factor (TNF-α) of rat vascular smooth muscle cells (VSMCs) and on the neointima formation after balloon injury of rat carotid artery. Primary rat VSMCs were identified by immunofluorescence assay. The proliferation of VSMCs induced by TNF-α was significantly inhibited by Artemisinin treatment in a dose-dependent manner.|
Current Science, 2000 , 78 (6) :709-713.
|Antimicrobial activity of artemisinin and its precursors.[Reference: WebLink]|
|Artemisinic acid and Arteannuin B are biogenetic precursors of Artemisinin, an important antimalarial produced by the herb Artemisia annua. These compounds have been screened for antimicrobial activity against a range of organisms. All the three compounds are active against different bacteria and certain fungal species.|